HT-0712 | CAS#617720-02-2 | phosphodiesterase (PDE4) inhibitor

MedKoo Cat#: 529702 | Name: HT-0712

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HT-0712 is phosphodiesterase (PDE4) inhibitor potentially for the treatment of age-associated memory impairment.

Chemical Structure

HT-0712

CAS#617720-02-2

Theoretical Analysis

MedKoo Cat#: 529702

Name: HT-0712

CAS#: 617720-02-2

Chemical Formula: C25H31NO3

Exact Mass: 393.2304

Molecular Weight: 393.52

Elemental Analysis: C, 76.30; H, 7.94; N, 3.56; O, 12.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

HT-0712; IPL-455903; HT0712; IPL455903; HT 0712; IPL 455903

IUPAC/Chemical Name

(3S,5S)-5-(3-(cyclopentyloxy)-4-methoxyphenyl)-3-(3-methylbenzyl)piperidin-2-one

InChi Key

ABEJDMOBAFLQNJ-NHCUHLMSSA-N

InChi Code

InChI=1S/C25H31NO3/c1-17-6-5-7-18(12-17)13-20-14-21(16-26-25(20)27)19-10-11-23(28-2)24(15-19)29-22-8-3-4-9-22/h5-7,10-12,15,20-22H,3-4,8-9,13-14,16H2,1-2H3,(H,26,27)/t20-,21-/m1/s1

SMILES Code

O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C[C@H]1CC4=CC=CC(C)=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 393.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Peters M, Bletsch M, Stanley J, Wheeler D, Scott R, Tully T. The PDE4 inhibitor HT-0712 improves hippocampus-dependent memory in aged mice. Neuropsychopharmacology. 2014 Dec;39(13):2938-48. doi: 10.1038/npp.2014.154. PubMed PMID: 24964813; PubMed Central PMCID: PMC4229572. 2: MacDonald E, Van der Lee H, Pocock D, Cole C, Thomas N, VandenBerg PM, Bourtchouladze R, Kleim JA. A novel phosphodiesterase type 4 inhibitor, HT-0712, enhances rehabilitation-dependent motor recovery and cortical reorganization after focal cortical ischemia. Neurorehabil Neural Repair. 2007 Nov-Dec;21(6):486-96. PubMed PMID: 17823313. 3: Giembycz MA. Can the anti-inflammatory potential of PDE4 inhibitors be realized: guarded optimism or wishful thinking? Br J Pharmacol. 2008 Oct;155(3):288-90. doi: 10.1038/bjp.2008.297. PubMed PMID: 18660832; PubMed Central PMCID: PMC2567889.