Synonym
LGD-2941; LGD 2941; LGD2941
IUPAC/Chemical Name
6-((2R,5R)-2-methyl-5-((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-4-(trifluoromethyl)quinolin-2(1H)-one
InChi Key
HWLLYFXDDGGHOE-BCSUUIJWSA-N
InChi Code
InChI=1S/C17H16F6N2O2/c1-8-2-5-13(15(27)17(21,22)23)25(8)9-3-4-12-10(6-9)11(16(18,19)20)7-14(26)24-12/h3-4,6-8,13,15,27H,2,5H2,1H3,(H,24,26)/t8-,13-,15-/m1/s1
SMILES Code
O=C1NC2=C(C=C(N3[C@H](C)CC[C@@H]3[C@@H](O)C(F)(F)F)C=C2)C(C(F)(F)F)=C1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Biological target:
LGD-2941 is an androgen receptor modulator for the treatment of hypogonadism, female sexual dysfunction and menopausal syndrome.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
394.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Riedmaier I, Tichopad A, Reiter M, Pfaffl MW, Meyer HH. Influence of testosterone and a novel SARM on gene expression in whole blood of Macaca fascicularis. J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):167-73. doi: 10.1016/j.jsbmb.2009.01.019. PubMed PMID: 19429447.
2: Reiter M, Tichopad A, Riedmaier I, Pfaffl MW, Meyer HH. Monitoring gene expression in muscle tissue of macaca fascicularis under the influence of testosterone and SARM. Horm Mol Biol Clin Investig. 2010 Jan 1;1(2):73-9. doi: 10.1515/HMBCI.2010.007. PubMed PMID: 25961973.
3: Furuya K. [Bone and Men's Health. Bone selective androgen receptor modulators]. Clin Calcium. 2010 Feb;20(2):225-33. doi: CliCa1002225233. Review. Japanese. PubMed PMID: 20118515.
4: Martinborough E, Shen Y, Oeveren Av, Long YO, Lau TL, Marschke KB, Chang WY, López FJ, Vajda EG, Rix PJ, Viveros OH, Negro-Vilar A, Zhi L. Substituted 6-(1-pyrrolidine)quinolin-2(1H)-ones as novel selective androgen receptor modulators. J Med Chem. 2007 Oct 18;50(21):5049-52. PubMed PMID: 17887661.
