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MedKoo Cat#: 529804 | Name: CORT-108297

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CORT-108297 is discontinued.

Chemical Structure

CORT-108297
CAS#1018679-79-2

Theoretical Analysis

MedKoo Cat#: 529804

Name: CORT-108297

CAS#: 1018679-79-2

Chemical Formula: C26H25F4N3O3S

Exact Mass: 535.1600

Molecular Weight: 535.56

Elemental Analysis: C, 58.31; H, 4.71; F, 14.19; N, 7.85; O, 8.96; S, 5.99

Price and Availability

This product was removed for the commercial reasons.
Related CAS #
No Data
Synonym
CORT-108297; CORT 108297; CORT108297; C-108927; C 108927; C108927
IUPAC/Chemical Name
(R)-4a-(ethoxymethyl)-1-(4-fluorophenyl)-6-((4-(trifluoromethyl)phenyl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinoline
InChi Key
SLKURXRZHJOZOD-RUZDIDTESA-N
InChi Code
InChI=1S/C26H25F4N3O3S/c1-2-36-17-25-14-18-15-31-33(22-7-5-21(27)6-8-22)24(18)13-20(25)11-12-32(16-25)37(34,35)23-9-3-19(4-10-23)26(28,29)30/h3-10,13,15H,2,11-12,14,16-17H2,1H3/t25-/m1/s1
SMILES Code
O=S(N1C[C@@]2(COCC)CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C2CC1)(C5=CC=C(C(F)(F)F)C=C5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 535.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Solomon MB, Wulsin AC, Rice T, Wick D, Myers B, McKlveen J, Flak JN, Ulrich-Lai Y, Herman JP. The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test. Horm Behav. 2014 Apr;65(4):363-71. doi: 10.1016/j.yhbeh.2014.02.002. PubMed PMID: 24530653; PubMed Central PMCID: PMC4074011. 2: Sindelar DK, Carson MW, Morin M, Shaw J, Barr RJ, Need A, Alexander-Chacko J, Coghlan M, Gehlert DR. LLY-2707, a novel nonsteroidal glucocorticoid antagonist that reduces atypical antipsychotic-associated weight gain in rats. J Pharmacol Exp Ther. 2014 Jan;348(1):192-201. doi: 10.1124/jpet.113.205864. PubMed PMID: 24163440. 3: Belanoff JK, Blasey CM, Clark RD, Roe RL. Selective glucocorticoid receptor (type II) antagonist prevents and reverses olanzapine-induced weight gain. Diabetes Obes Metab. 2010 Jun;12(6):545-7. doi: 10.1111/j.1463-1326.2009.01185.x. PubMed PMID: 20518810. 4: Asagami T, Belanoff JK, Azuma J, Blasey CM, Clark RD, Tsao PS. Selective Glucocorticoid Receptor (GR-II) Antagonist Reduces Body Weight Gain in Mice. J Nutr Metab. 2011;2011:235389. doi: 10.1155/2011/235389. PubMed PMID: 21811679; PubMed Central PMCID: PMC3146995. 5: Andrade C, Shaikh SA, Narayan L, Blasey C, Belanoff J. Administration of a selective glucocorticoid antagonist attenuates electroconvulsive shock-induced retrograde amnesia. J Neural Transm (Vienna). 2012 Mar;119(3):337-44. doi: 10.1007/s00702-011-0712-8. PubMed PMID: 21922193. 6: Butts KA, Phillips AG. Glucocorticoid receptors in the prefrontal cortex regulate dopamine efflux to stress via descending glutamatergic feedback to the ventral tegmental area. Int J Neuropsychopharmacol. 2013 Sep;16(8):1799-807. doi: 10.1017/S1461145713000187. PubMed PMID: 23590841. 7: Meyer M, Gonzalez Deniselle MC, Hunt H, de Kloet ER, De Nicola AF. The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice. J Steroid Biochem Mol Biol. 2014 Sep;143:40-8. doi: 10.1016/j.jsbmb.2014.02.007. PubMed PMID: 24565565. 8: Magistrelli D, Rosi F. Trend analysis of plasma insulin level around parturition in relation to parity in Saanen goats. J Anim Sci. 2014 Jun;92(6):2440-6. doi: 10.2527/jas.2013-6993. PubMed PMID: 24778336. 9: O'Callaghan JP, Kelly KA, VanGilder RL, Sofroniew MV, Miller DB. Early activation of STAT3 regulates reactive astrogliosis induced by diverse forms of neurotoxicity. PLoS One. 2014 Jul 15;9(7):e102003. doi: 10.1371/journal.pone.0102003. PubMed PMID: 25025494; PubMed Central PMCID: PMC4098997. 10: Nguyen ET, Streicher J, Berman S, Caldwell JL, Ghisays V, Estrada CM, Wulsin AC, Solomon MB. A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats. Physiol Behav. 2017 Jan 13. pii: S0031-9384(16)30671-0. doi: 10.1016/j.physbeh.2017.01.020. [Epub ahead of print] PubMed PMID: 28093219.