ADL-5747 | CAS#1187653-56-0 (HCl) | CAS#850176-30-6 (Free base) | opioid delta receptor

MedKoo Cat#: 529917 | Name: ADL-5747 (HCl)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ADL-5747, also known as PF-4856881, is an opioid delta receptor agonist potentially for the treatment of pain.

Chemical Structure

ADL-5747 (HCl)

CAS#1187653-56-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 529917

Name: ADL-5747 (HCl)

CAS#: 1187653-56-0 (HCl)

Chemical Formula: C24H29ClN2O3

Exact Mass:

Molecular Weight: 428.96

Elemental Analysis: C, 67.20; H, 6.81; Cl, 8.26; N, 6.53; O, 11.19

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

850176-30-6 (Free base)

Synonym

PF-4856881; PF-04856881; PF4856881; PF04856881; PF 4856881; PF 04856881; ADL-5747; ADL 5747; ADL5747;

IUPAC/Chemical Name

N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidin]-4-yl)benzamide hydrochloride

InChi Key

XROFSGVHHSJMMG-UHFFFAOYSA-N

InChi Code

InChI=1S/C24H28N2O3.ClH/c1-3-26(4-2)23(28)17-9-10-18(21(27)15-17)20-16-24(11-13-25-14-12-24)29-22-8-6-5-7-19(20)22;/h5-10,15-16,25,27H,3-4,11-14H2,1-2H3;1H

SMILES Code

O=C(N(CC)CC)C1=CC=C(C2=CC3(CCNCC3)OC4=C2C=CC=C4)C(O)=C1.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 428.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Le Bourdonnec B, Windh RT, Leister LK, Zhou QJ, Ajello CW, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE. Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747). J Med Chem. 2009 Sep 24;52(18):5685-702. doi: 10.1021/jm900773n. PubMed PMID: 19694468. 2: Nozaki C, Le Bourdonnec B, Reiss D, Windh RT, Little PJ, Dolle RE, Kieffer BL, Gavériaux-Ruff C. δ-Opioid mechanisms for ADL5747 and ADL5859 effects in mice: analgesia, locomotion, and receptor internalization. J Pharmacol Exp Ther. 2012 Sep;342(3):799-807. doi: 10.1124/jpet.111.188987. PubMed PMID: 22700431; PubMed Central PMCID: PMC3422521.