RPR-106541 |CAS#159001-35-1 | GR agonist

MedKoo Cat#: 529910 | Name: RPR-106541

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RPR-106541 is a GR agonist potentially for the treatment of asthma

Chemical Structure

RPR-106541

CAS#159001-35-1

Theoretical Analysis

MedKoo Cat#: 529910

Name: RPR-106541

CAS#: 159001-35-1

Chemical Formula: C24H34F2O4S

Exact Mass: 456.2100

Molecular Weight: 456.59

Elemental Analysis: C, 63.13; H, 7.51; F, 8.32; O, 14.02; S, 7.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

RPR-106541; RPR106541; RPR 106541

IUPAC/Chemical Name

(20R)-16a,17a-Butylidenedioxy-6a,9a-difluoro-11b-hydroxy-17b-(methylthio)androst-4-en-3-one

InChi Key

QGBIFMJAQARMNQ-QISPFCDLSA-N

InChi Code

InChI=1S/C24H34F2O4S/c1-5-6-20-29-19-11-14-15-10-17(25)16-9-13(27)7-8-21(16,2)23(15,26)18(28)12-22(14,3)24(19,30-20)31-4/h9,14-15,17-20,28H,5-8,10-12H2,1-4H3/t14-,15-,17-,18-,19+,20+,21-,22-,23-,24-/m0/s1

SMILES Code

CCC[C@@H]1O[C@@H]2C[C@H]3[C@@H]4C[C@@H](C5=CC(CC[C@@]5([C@]4([C@H](C[C@@]3([C@]2(SC)O1)C)O)F)C)=O)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 456.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Miller GK, Valerio MG, Pino MV, Larson JL, Viau A, Hamelin N, Labbé R, Banks CM. Chronic effects of the novel glucocorticosteroid RPR 106541 administered to beagle dogs by inhalation. Toxicol Pathol. 2000 Mar-Apr;28(2):226-36. PubMed PMID: 10805140. 2: Stevens JC, Domanski TL, Harlow GR, White RB, Orton E, Halpert JR. Use of the steroid derivative RPR 106541 in combination with site-directed mutagenesis for enhanced cytochrome P-450 3A4 structure/function analysis. J Pharmacol Exp Ther. 1999 Aug;290(2):594-602. PubMed PMID: 10411567. 3: Underwood SL, Raeburn D, Lawrence C, Foster M, Webber S, Karlsson JA. RPR 106541, a novel, airways-selective glucocorticoid: effects against antigen-induced CD4+ T lymphocyte accumulation and cytokine gene expression in the Brown Norway rat lung. Br J Pharmacol. 1997 Oct;122(3):439-46. PubMed PMID: 9351499; PubMed Central PMCID: PMC1564957.