AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
MedKoo Cat#: 407353
Name: AMG-47a
CAS#: 882663-88-9
Chemical Formula: C29H28F3N5O2
Exact Mass: 535.2195
Molecular Weight: 535.57
Elemental Analysis: C, 65.04; H, 5.27; F, 10.64; N, 13.08; O, 5.97
The following data is based on the product molecular weight 535.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
