MedKoo Cat#: 406999 | Name: MDK25371
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

MDK25371, also known as USP7-USP47 inhibitor, is a USP7-USP47 inhibitor. MDK25371 has CAS#1247825-37-1. In its name, the last 5-digit CAS# was used. USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells.

Chemical Structure

MDK25371
MDK25371
CAS#1247825-37-1

Theoretical Analysis

MedKoo Cat#: 406999

Name: MDK25371

CAS#: 1247825-37-1

Chemical Formula: C18H11Cl2N3O3S3

Exact Mass: 482.9340

Molecular Weight: 484.38

Elemental Analysis: C, 44.63; H, 2.29; Cl, 14.64; N, 8.68; O, 9.91; S, 19.86

Price and Availability

Size Price Availability Quantity
5mg USD 295.00 2 Weeks
10mg USD 500.00 2 Weeks
25mg USD 950.00 2 Weeks
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Related CAS #
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Synonym
MDK25371; MDK25371; MDK25371; USP7-USP47 inhibitor.
IUPAC/Chemical Name
(Z)-4-cyano-5-((3,5-dichloropyridin-4-yl)thio)-N-(4-(methylsulfonyl)phenyl)thiophene-2-carbimidic acid
InChi Key
GUDJFFQZIISQJB-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H11Cl2N3O3S3/c1-29(25,26)12-4-2-11(3-5-12)23-17(24)15-6-10(7-21)18(27-15)28-16-13(19)8-22-9-14(16)20/h2-6,8-9H,1H3,(H,23,24)
SMILES Code
O/C(C1=CC(C#N)=C(SC2=C(Cl)C=NC=C2Cl)S1)=N\C3=CC=C(S(=O)(C)=O)C=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 484.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
[1]. Weinstock J, et al. Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. ACS Med Chem Lett. 2012 Sep 11;3(10):789-92.