Synonym
Nuvenzepine; Nuvenzepinum;
IUPAC/Chemical Name
11-(1-methylpiperidine-4-carbonyl)-6,11-dihydro-5H-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one
InChi Key
HPKYRXAEGNUARA-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H20N4O2/c1-22-11-8-13(9-12-22)19(25)23-16-7-3-2-6-15(16)21-18(24)14-5-4-10-20-17(14)23/h2-7,10,13H,8-9,11-12H2,1H3,(H,21,24)
SMILES Code
O=C1C2=CC=CN=C2N(C(C3CCN(C)CC3)=O)C4=CC=CC=C4N1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
336.40
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Barocelli E, Ballabeni V, Chiavarini M, Molina E, Impicciatore M. Functional comparison between nuvenzepine and pirenzepine on different guinea pig isolated smooth muscle preparations. Pharmacol Res. 1994 Aug-Sep;30(2):161-70. PubMed PMID: 7816744.
2: Caselli G, Ferrari MP, Tonon G, Clavenna G, Borsa M. Determination of nuvenzepine in human plasma by a sensitive [3H]pirenzepine radioreceptor binding assay. J Pharm Sci. 1991 Feb;80(2):173-7. PubMed PMID: 2051325.
3: Barocelli E, Chiavarini M, Gentile A, Lavezzo A, Impicciatore M. Gastrointestinal activities of a new pirenzepine-analog, nuvenzepine, in the cat. Farmaco. 1990 Oct;45(10):1089-99. PubMed PMID: 2095154.
4: Barocelli E, Ballabeni V, Chiavarini M, Caretta A, Molina E, Impicciatore M. Regional differences in motor responsiveness to antimuscarinic drugs in rabbit isolated small and large intestine. Pharmacol Res. 1995 Jan;31(1):43-8. PubMed PMID: 7784305.
5: Novelli F, Sparatore A, Tasso B, Sparatore F. Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors. Bioorg Med Chem Lett. 1999 Oct 18;9(20):3031-4. PubMed PMID: 10571170.
6: Barocelli E, Ballabeni V, Chiavarini M, Molina E, Lavezzo A, Impicciatore M. Muscarinic M1 and M3 receptor antagonist effects of a new pirenzepine analogue in isolated guinea-pig ileal longitudinal muscle-myenteric plexus. Eur J Pharmacol. 1994 Mar 11;254(1-2):151-7. PubMed PMID: 7515819.
7: Barocelli E, Morini G, Ballabeni V, Lavezzo A, Impicciatore M. Effects of two new pirenzepine analogs on the contractile response of the guinea-pig oesophageal muscularis mucosae to acetylcholine, bethanechol, histamine and high potassium. Eur J Pharmacol. 1990 Apr 10;179(1-2):89-96. PubMed PMID: 1973103.
8: Eltze M, Mutschler E, Lambrecht G. Affinity profiles of pizotifen, ketotifen and other tricyclic antimuscarinics at muscarinic receptor subtypes M1, M2 and M3. Eur J Pharmacol. 1992 Feb 18;211(3):283-93. PubMed PMID: 1377628.
