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MedKoo Cat#: 530013 | Name: Senazodan HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Senazodan HCl, also known MCI-154, is a phosphodiesterase inhibitor potentially for the treatment of heart failure.

Chemical Structure

Senazodan HCl
CAS#98326-33-1

Theoretical Analysis

MedKoo Cat#: 530013

Name: Senazodan HCl

CAS#: 98326-33-1

Chemical Formula: C15H15ClN4O

Exact Mass:

Molecular Weight: 302.76

Elemental Analysis: C, 59.51; H, 4.99; Cl, 11.71; N, 18.51; O, 5.28

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Senazodan hydrochloride; MCI-154; MCI154; MCI 154
IUPAC/Chemical Name
6-(4-(pyridin-4-ylamino)phenyl)-4,5-dihydropyridazin-3(2H)-one hydrochloride
InChi Key
InChi Code
SMILES Code
O=C1CCC(C2=CC=C(NC3=CC=NC=C3)C=C2)=NN1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
More Info
Related CAS# 98326-32-0 (Senazodan free base) 98326-33-1 (Senazodan HCl)

Preparing Stock Solutions

The following data is based on the product molecular weight 302.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Yang G, Liu L, Xu J, Li T. Effects of MCI-154 on vascular reactivity and its mechanisms after hemorrhagic shock in rats. J Cardiovasc Pharmacol. 2006 Jun;47(6):751-7. PubMed PMID: 16810075. 2: Yang GM, Liu LM. [Effect of MCI-154 on calcium sensitivity of vascular smooth muscle and its mechanism in hemorrhagic shock in rats]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Jan;17(1):7-11. Chinese. PubMed PMID: 15636703. 3: Chen HZ, Cui XL, Zhao HC, Zhao LY, Lu JY, Wu BW. Inotropic effects of MCI-154 on rat cardiac myocytes. Sheng Li Xue Bao. 2004 Jun 25;56(3):301-5. PubMed PMID: 15224141. 4: Takahashi S, Cho S, Hara T, Ureshino H, Tomiyasu S, Sumikawa K. The interaction of MCI-154, a calcium sensitizer, and isoflurane on systemic and coronary hemodynamics in chronically instrumented dogs. Anesth Analg. 2004 Jan;98(1):30-6, table of contents. PubMed PMID: 14693578. 5: Okafor C, Liao R, Perreault-Micale C, Li X, Ito T, Stepanek A, Doye A, de Tombe P, Gwathmey JK. Mg-ATPase and Ca+ activated myosin AtPase activity in ventricular myofibrils from non-failing and diseased human hearts--effects of calcium sensitizing agents MCI-154, DPI 201-106, and caffeine. Mol Cell Biochem. 2003 Mar;245(1-2):77-89. PubMed PMID: 12708747. 6: Korvald C, Nordhaug DO, Steensrud T, Aghajani E, Myrmel T. Vasodilation and mechanoenergetic inefficiency dominates the effect of the "Ca(2+)-sensitizer" MCI-154 in intact pigs. Scand Cardiovasc J. 2002 May;36(3):172-9. PubMed PMID: 12079638. 7: Ming MJ, Hu D, Chen HS, Liu LM, Nan X, Hua CH, Lu RQ. Effect of MCI-154, a calcium sensitizer, on calcium sensitivity of myocardial fibers in endotoxic shock rats. Shock. 2000 Dec;14(6):652-6. PubMed PMID: 11131917. 8: Mei JM, Hu DY, Chen HS, Liu LM, Xiao N, Chen HH, Lu RQ. Effects of MCI-154, a calcium sensitizer, on cardiac function in endotoxemic rabbits. Acta Pharmacol Sin. 2000 Sep;21(9):824-9. PubMed PMID: 11501165. 9: Mei JM, Hu DY, Chen HS, Liu LM, Xiao N, Chen HH, Lu RQ. Effect of MCI-154, a calcium sensitizer, on calcium sensitivity of myocardial contractile system in endotoxemic rats. Acta Pharmacol Sin. 2000 Sep;21(9):830-4. PubMed PMID: 11501166. 10: Ming MJ, Hu DY, Chen HS, Liu LM, Nan X, Lu RQ. Effects of MCI-154, a calcium sensitizer, on cardiac dysfunction in endotoxic shock in rabbits. Shock. 2000 Jun;13(6):459-63. PubMed PMID: 10847633. 11: Kawasumi H, Abe Y, Ishibashi A, Kitada Y. MCI-154, a Ca2+ sensitizer, increases survival in cardiomyopathic hamsters. Eur J Pharmacol. 1999 May 14;372(2):175-8. PubMed PMID: 10395097. 12: Kumamoto H, Okamoto H, Watanabe M, Onozuka H, Yoneya K, Nakagawa I, Chiba S, Watanabe S, Mikami T, Abe K, Kitabatake A. Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154. Am J Physiol. 1999 Apr;276(4 Pt 2):H1117-23. PubMed PMID: 10199832. 13: Eto K, Hashimoto K, Nakaya H. Preferential inhibition of Ikr by MCI-154, a putative cardiotonic Ca2+ sensitizer, in guinea pig atrial cells. Cardiovasc Res. 1998 Jun;38(3):685-94. PubMed PMID: 9747436. 14: Duncker DJ, Verdouw PD. Inotropic therapy of heart failure. Editorial comments on: Vasodilation and mechanoenergetic inefficiency dominates the effect of the "Ca2+ sensitizer" MCI-154 in intact pigs. Scand Cardiovasc J. 2002 May;36(3):131-5. Review. PubMed PMID: 12079634. 15: Iwamoto H. Effect of a cardiotonic agent, MCI-154, on the contractile properties of skinned skeletal muscle fibers. Eur J Pharmacol. 1998 Jan 12;341(2-3):243-52. PubMed PMID: 9543245. 16: Kitada Y. MCI-154, a cardiac Ca2+ sensitizer, reverses the depression in maximal Ca2+-activated force by inorganic phosphate and acidic pH in skinned fiber of guinea pig heart. Cardiovasc Drugs Ther. 1997 Nov;11(5):611-8. PubMed PMID: 9493698. 17: Onishi K, Sekioka K, Ishisu R, Abe Y, Tanaka H, Nakamura M, Ueda Y, Nakano T. MCI-154, a Ca2+ sensitizer, decreases the oxygen cost of contractility in isolated canine hearts. Am J Physiol. 1997 Oct;273(4 Pt 2):H1688-95. PubMed PMID: 9362231. 18: Huang Y, He ZH, Li YX. Effects of MCI-154 on calcium sensitivity of contractile system and calcium release from sarcoplasmic reticulum in saponin-skinned rat myocardium. Zhongguo Yao Li Xue Bao. 1997 May;18(3):234-7. PubMed PMID: 10072940. 19: Mori M, Takeuchi M, Takaoka H, Hata K, Hayashi Y, Yamakawa H, Yokoyama M. Oxygen-saving effect of a new cardiotonic agent, MCI-154, in diseased human hearts. J Am Coll Cardiol. 1997 Mar 1;29(3):613-22. PubMed PMID: 9060901. 20: Takaoka H, Takeuchi M, Hata K, Hayashi Y, Mori M, Yamakawa H, Yamaguchi K, Yokoyama M. Beneficial effects of a Ca2+ sensitizer, MCI-154, on the myocardial oxygen consumption-cardiac output relation in patients with left ventricular dysfunction after myocardial infarction: comparison with dobutamine and phosphodiesterase inhibitor. Am Heart J. 1997 Mar;133(3):283-9. PubMed PMID: 9060795.

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