ML346 is a Hsp70 activator and a Novel Modulator of Proteostasis for Protein Conformational Diseases. ML346 belongs to the barbituric acid scaffold. ML346 induces HSF-1-dependent chaperone expression and restores protein folding in conformational disease models. These effects are mediated by novel mechanisms involving FOXO, HSF-1, and Nfr-2.
MedKoo Cat#: 530368
Name: ML346
CAS#: 100872-83-1
Chemical Formula: C14H12N2O4
Exact Mass: 272.0797
Molecular Weight: 272.26
Elemental Analysis: C, 61.76; H, 4.44; N, 10.29; O, 23.51
| Solvent | mg/mL | mM | comments | |
|---|---|---|---|---|
| Solubility | ||||
| Soluble in DMSO | 8.0 | 29.38 |
The following data is based on the product molecular weight 272.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
