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MedKoo Cat#: 526482 | Name: Triadimefon
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Triadimefon is a systemic fungicide from the triazole class that inhibits ergosterol biosynthesis by targeting lanosterol 14α-demethylase, disrupting fungal cell membrane formation. It is effective against a wide range of fungal pathogens, including powdery mildew, rusts, and leaf spots, in crops such as cereals, fruits, and ornamental plants. Triadimefon exhibits moderate persistence in soil and plants, with low acute toxicity to mammals, making it widely used in agricultural and horticultural disease management.

Chemical Structure

Triadimefon
Triadimefon
CAS#43121-43-3

Theoretical Analysis

MedKoo Cat#: 526482

Name: Triadimefon

CAS#: 43121-43-3

Chemical Formula: C14H16ClN3O2

Exact Mass: 293.0931

Molecular Weight: 293.75

Elemental Analysis: C, 57.24; H, 5.49; Cl, 12.07; N, 14.30; O, 10.89

Price and Availability

Size Price Availability Quantity
1g USD 215.00
5g USD 380.00
10g USD 600.00
25g USD 1,000.00
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Related CAS #
No Data
Synonym
Triadimefon
IUPAC/Chemical Name
1-(4-Chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butanone
InChi Key
WURBVZBTWMNKQT-UHFFFAOYSA-N
InChi Code
InChI=1S/C14H16ClN3O2/c1-14(2,3)12(19)13(18-9-16-8-17-18)20-11-6-4-10(15)5-7-11/h4-9,13H,1-3H3
SMILES Code
CC(C)(C)C(C(OC1=CC=C(Cl)C=C1)N2N=CN=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 293.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Li J, Chang J, Li W, Guo B, Li J, Wang H. Disruption of sex-hormone levels and steroidogenic-related gene expression on Mongolia Racerunner (Eremias argus) after exposure to triadimefon and its enantiomers. Chemosphere. 2016 Dec 22;171:554-563. doi: 10.1016/j.chemosphere.2016.12.096. [Epub ahead of print] PubMed PMID: 28039834. 2: Xu P, Huang L. Stereoselective bioaccumulation, transformation, and toxicity of triadimefon in Scenedesmus obliquus. Chirality. 2016 Dec 23. doi: 10.1002/chir.22671. [Epub ahead of print] PubMed PMID: 28009445. 3: Kong Z, Li M, An J, Chen J, Bao Y, Francis F, Dai X. The fungicide triadimefon affects beer flavor and composition by influencing Saccharomyces cerevisiae metabolism. Sci Rep. 2016 Sep 15;6:33552. doi: 10.1038/srep33552. PubMed PMID: 27629523; PubMed Central PMCID: PMC5024320. 4: Cao C, Wang Q, Jiao F, Zhu G. Impact of co-exposure with butachlor and triadimefon on thyroid endocrine system in larval zebrafish. Exp Toxicol Pathol. 2016 Sep;68(8):463-9. doi: 10.1016/j.etp.2016.07.004. PubMed PMID: 27480594. 5: Paul Friedman K, Papineni S, Marty MS, Yi KD, Goetz AK, Rasoulpour RJ, Kwiatkowski P, Wolf DC, Blacker AM, Peffer RC. A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study. Crit Rev Toxicol. 2016 Oct;46(9):785-833. doi: 10.1080/10408444.2016.1193722. PubMed PMID: 27347635; PubMed Central PMCID: PMC5044773. 6: Li M, Li S, Yao T, Zhao R, Wang Q, Zhu G. Waterborne exposure to triadimefon causes thyroid endocrine disruption and developmental delay in Xenopus laevis tadpoles. Aquat Toxicol. 2016 Aug;177:190-7. doi: 10.1016/j.aquatox.2016.05.018. PubMed PMID: 27289584. 7: Hsu LS, Chiou BH, Hsu TW, Wang CC, Chen SC. The regulation of transcriptome responses in zebrafish embryo exposure to triadimefon. Environ Toxicol. 2017 Jan;32(1):217-226. doi: 10.1002/tox.22227. PubMed PMID: 26790661. 8: Pallocca G, Grinberg M, Henry M, Frickey T, Hengstler JG, Waldmann T, Sachinidis A, Rahnenführer J, Leist M. Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80. doi: 10.1007/s00204-015-1658-7. PubMed PMID: 26705709; PubMed Central PMCID: PMC4710658. 9: Yao Z, Li X, Miao Y, Lin M, Xu M, Wang Q, Zhang H. Simultaneous enantioselective determination of triadimefon and its metabolite triadimenol in edible vegetable oil by gel permeation chromatography and ultraperformance convergence chromatography/tandem mass spectrometry. Anal Bioanal Chem. 2015 Nov;407(29):8849-59. doi: 10.1007/s00216-015-9046-y. PubMed PMID: 26416018.