Synonym
Relacorilant, CORT125134; CORT-125134; CORT 125134.
IUPAC/Chemical Name
[(4aR)-1-(4-fluorophenyl)-6-(1-methyl-1H-pyrazole-4-sulfonyl)-1,4,5,6,7,8-hexahydro-4aH-pyrazolo[3,4-g]isoquinolin-4a-yl][4-(trifluoromethyl)pyridin-
2-yl]methanone
InChi Key
WANIDIGFXJFFEL-SANMLTNESA-N
InChi Code
InChI=1S/C27H22F4N6O3S/c1-35-15-22(14-33-35)41(39,40)36-9-7-18-11-24-17(13-34-37(24)21-4-2-20(28)3-5-21)12-26(18,16-36)25(38)23-10-19(6-8-32-23)27(29,30)31/h2-6,8,10-11,13-15H,7,9,12,16H2,1H3/t26-/m0/s1
SMILES Code
O=C([C@]12CC3=C(N(C4=CC=C(F)C=C4)N=C3)C=C1CCN(S(=O)(C5=CN(C)N=C5)=O)C2)C6=NC=CC(C(F)(F)F)=C6
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
586.57
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hunt HJ, Belanoff JK, Walters I, Gourdet B, Thomas J, Barton N, Unitt J,
Phillips T, Swift D, Eaton E. Identification of the Clinical Candidate
(R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexah
ydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methano
ne (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist. J Med Chem.
2017 Apr 17. doi: 10.1021/acs.jmedchem.7b00162. [Epub ahead of print] PubMed
PMID: 28368581.
2: Bali U, Phillips T, Hunt H, Unitt J. FKBP5 mRNA Expression Is a Biomarker for
GR Antagonism. J Clin Endocrinol Metab. 2016 Nov;101(11):4305-4312. Epub 2016 Jul
26. PubMed PMID: 27459525.
3: Stringer-Reasor EM, Baker GM, Skor MN, Kocherginsky M, Lengyel E, Fleming GF,
Conzen SD. Glucocorticoid receptor activation inhibits chemotherapy-induced cell
death in high-grade serous ovarian carcinoma. Gynecol Oncol. 2015
Sep;138(3):656-62. doi: 10.1016/j.ygyno.2015.06.033. Epub 2015 Jun 24. PubMed
PMID: 26115975; PubMed Central PMCID: PMC4556542.
