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MedKoo Cat#: 530007 | Name: Estredox

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Estredox, also known as E2-CDS, is an estrogen receptor agonist potentially for the treatment of vasomotor symptoms.

Chemical Structure

Estredox
Estredox
CAS#103562-82-9

Theoretical Analysis

MedKoo Cat#: 530007

Name: Estredox

CAS#: 103562-82-9

Chemical Formula: C25H31NO3

Exact Mass: 393.2300

Molecular Weight: 393.53

Elemental Analysis: C, 76.30; H, 7.94; N, 3.56; O, 12.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
IDR-90104; E-2-CDS; E-2CDS; IDR 90104; E 2 CDS; E 2CDS; IDR90104; E2CDS;
IUPAC/Chemical Name
(3-Hydroxy-17-((1-methyl-1,4-dihydropyridin-3-yl)carbonyl)oxy)estra-1,3,5(10)-triene
InChi Key
KTMLJZFJHDUEAU-ZZDGKJOTSA-N
InChi Code
InChI=1S/C25H31NO3/c1-25-12-11-20-19-8-6-18(27)14-16(19)5-7-21(20)22(25)9-10-23(25)29-24(28)17-4-3-13-26(2)15-17/h3,6,8,13-15,20-23,27H,4-5,7,9-12H2,1-2H3/t20-,21-,22+,23?,25+/m1/s1
SMILES Code
C[C@@]12C(OC(C3=CN(C)C=CC3)=O)CC[C@@]1([H])[C@]4([H])CCC5=C(C=CC(O)=C5)[C@@]4([H])CC2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 393.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Prokai-Tatrai K, Szarka S, Nguyen V, Sahyouni F, Walker C, White S, Talamantes T, Prokai L. "All in the mind"? Brain-targeting chemical delivery system of 17β-estradiol (Estredox) produces significant uterotrophic side effect. Pharm Anal Acta. 2012;Suppl 7. doi: 10.4172/2153-2435.S7-002. PubMed PMID: 24380028; PubMed Central PMCID: PMC3874273. 2: Patthy M, Seres G, Tóth-Sarudy E, Hazai I, Pallagi I, Simay A, Bodor N. Determination of estredox, a compound with sustained estradiol function, and its impurity profile by HPLC. Pharmazie. 2008 Mar;63(3):210-6. PubMed PMID: 18444509. 3: Sziráki I, Horváth K, Bodor N. Comparative evaluation of Estredox, a brain-targeted estradiol delivery system versus traditional estrogen replacement therapy. Pharmazie. 2006 Feb;61(2):140-3. PubMed PMID: 16526562. 4: Tapfer MK, Sebestyen L, Kurucz I, Horvath K, Szelenyi I, Bodor N. New evidence for the selective, long-lasting central effects of the brain-targeted estradiol, Estredox. Pharmacol Biochem Behav. 2004 Mar;77(3):423-9. PubMed PMID: 15006452.