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MedKoo Cat#: 526465 | Name: Tolimidone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tolimidone, also known as MLR-1023, is a novel insulin receptor potentiator.

Chemical Structure

Tolimidone
CAS#41964-07-2

Theoretical Analysis

MedKoo Cat#: 526465

Name: Tolimidone

CAS#: 41964-07-2

Chemical Formula: C11H10N2O2

Exact Mass: 202.0742

Molecular Weight: 202.21

Elemental Analysis: C, 65.34; H, 4.98; N, 13.85; O, 15.82

Price and Availability

Size Price Availability Quantity
10mg USD 245.00 2 Weeks
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
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Related CAS #
No Data
Synonym
Tolimidone; CP 26,154; CP 26,154; CP 26,154; NSC 314335; MLR-1023; MLR 1023; MLR1023.
IUPAC/Chemical Name
5-(m-Tolyloxy)-2(1H)-pyrimidinone
InChi Key
HJQILFPVRNHTIG-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H,1H3,(H,12,13,14)
SMILES Code
O=C1N=CC(OC2=CC=CC(C)=C2)=CN1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 202.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Apolzan JW, LaRose JG, Anton SD, Beyl RA, Greenway FL, Wickham EP 3rd, Lanoye A, Harris MN, Martin CK, Bullard T, Foster GD, Cardel MI. A scalable, virtual weight management program tailored for adults with type 2 diabetes: effects on glycemic control. Nutr Diabetes. 2023 Apr 6;13(1):3. doi: 10.1038/s41387-023-00234-6. PMID: 37024467; PMCID: PMC10079927. 2: Rebello CJ, Coulter AA, Reaume AG, Cong W, Cusimano LA, Greenway FL. MLR-1023 Treatment in Mice and Humans Induces a Thermogenic Program, and Menthol Potentiates the Effect. Pharmaceuticals (Basel). 2021 Nov 22;14(11):1196. doi: 10.3390/ph14111196. PMID: 34832978; PMCID: PMC8625945. 3: Lipinski CA, Reaume AG. High throughput in vivo phenotypic screening for drug repurposing: Discovery of MLR-1023 a novel insulin sensitizer and novel Lyn kinase activator with clinical proof of concept. Bioorg Med Chem. 2020 May 1;28(9):115425. doi: 10.1016/j.bmc.2020.115425. Epub 2020 Mar 16. PMID: 32201192. 4: Lee MK, Kim SG, Watkins E, Moon MK, Rhee SY, Frias JP, Chung CH, Lee SH, Block B, Cha BS, Park HK, Kim BJ, Greenway F. A novel non-PPARgamma insulin sensitizer: MLR-1023 clinicalproof-of-concept in type 2 diabetes mellitus. J Diabetes Complications. 2020 May;34(5):107555. doi: 10.1016/j.jdiacomp.2020.107555. Epub 2020 Feb 2. PMID: 32019723. 5: Ding Y, Li C, Zhang Y, Ma P, Zhao T, Che D, Cao J, Wang J, Liu R, Zhang T, He L. Quercetin as a Lyn kinase inhibitor inhibits IgE-mediated allergic conjunctivitis. Food Chem Toxicol. 2020 Jan;135:110924. doi: 10.1016/j.fct.2019.110924. Epub 2019 Oct 28. Erratum in: Food Chem Toxicol. 2020 Oct;144:111653. doi: 10.1016/j.fct.2020.111653. PMID: 31672514. 6: Ochman AR, Lipinski CA, Handler JA, Reaume AG, Saporito MS. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid- onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J Pharmacol Exp Ther. 2012 Jul;342(1):23-32. doi: 10.1124/jpet.112.192187. Epub 2012 Mar 19. PMID: 22431203.

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