NS-638 | CAS#150493-34-8 | Ca(2+)-channel blocker

MedKoo Cat#: 530468 | Name: NS-638

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NS-638 is a Ca(2+)-channel blocker. NS-638 dose dependently inhibited K(+)-stimulated [45Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 microM, respectively. K(+)-stimulated intracellular Ca(2+)-elevation in cultured cerebellar granule cells was equipotently blocked with an IC50 value of 3.4 microM.

Chemical Structure

NS-638

CAS#150493-34-8

Theoretical Analysis

MedKoo Cat#: 530468

Name: NS-638

CAS#: 150493-34-8

Chemical Formula: C15H11ClF3N3

Exact Mass: 325.0594

Molecular Weight: 325.72

Elemental Analysis: C, 55.31; H, 3.40; Cl, 10.88; F, 17.50; N, 12.90

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,650.00	2 Weeks
1g	USD 4,250.00	2 Weeks
2g	USD 6,450.00	2 Weeks

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Related CAS #

No Data

Synonym

NS-638; NS 638; NS638.

IUPAC/Chemical Name

2-Amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole

InChi Key

GXQCVUZORDAARJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C15H11ClF3N3/c16-11-4-1-9(2-5-11)8-22-13-6-3-10(15(17,18)19)7-12(13)21-14(22)20/h1-7H,8H2,(H2,20,21)

SMILES Code

FC(C1=CC=C2C(N=C(N)N2CC3=CC=C(Cl)C=C3)=C1)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties.

In vitro activity:

NS-638 dose dependently inhibited K(+)-stimulated [45Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)-stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 microM, respectively. Reference: Neurol Res. 1995 Oct;17(5):353-60. https://pubmed.ncbi.nlm.nih.gov/8584126/

In vivo activity:

In the mouse middle cerebral artery occlusion (MCAO) model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, resulted in a 48% reduction in total infarct volume. Reference: Neurol Res. 1995 Oct;17(5):353-60. https://pubmed.ncbi.nlm.nih.gov/8584126/

	Solvent	mg/mL	mM
Solubility
	DMSO	19.5	59.87
	Ethanol	2.0	6.14

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 325.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PMID: 8584126.

In vitro protocol:

In vivo protocol:

NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties.

1: Møller A, Christophersen P, Drejer J, Axelsson O, Peters D, Jensen LH, Nielsen EO. Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638. Neurol Res. 1995 Oct;17(5):353-60. PubMed PMID: 8584126. 2: Olesen SP, Møller A, Mordvintcev PI, Busse R, Mülsch A. Regional measurements of NO formed in vivo during brain ischemia. Acta Neurol Scand. 1997 Apr;95(4):219-24. PubMed PMID: 9150812.