SU 5201 | CAS#114727-43-4 | IL-2 production inhibitor

MedKoo Cat#: 530466 | Name: SU 5201

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SU 5201 is an inhibitor of IL-2 production. It inhibits IL-2 production in peripheral blood mononuclear cells (PBMCs) with an IC50 value of 1 nM. SU 5201 also inhibits VEGF- or acidic FGF-induced proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations of 2.5 and 2.3 µM, respectively.

Chemical Structure

SU 5201

CAS#114727-43-4

Theoretical Analysis

MedKoo Cat#: 530466

Name: SU 5201

CAS#: 114727-43-4

Chemical Formula: C15H9Cl2NO

Exact Mass: 289.0061

Molecular Weight: 290.14

Elemental Analysis: C, 62.10; H, 3.13; Cl, 24.44; N, 4.83; O, 5.51

Price and Availability

Size	Price	Availability
1g	USD 2,850.00	2 Weeks
2g	USD 3,950.00	2 Weeks
5g	USD 5,750.00	2 Weeks

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Related CAS #

No Data

Synonym

NSC 247030; NSC-247030; NSC247030; SU 5201; SU5201; SU-5201;

IUPAC/Chemical Name

(3,4-Dichlorobenzylidene)-1,3-dihydroindol-2-one

InChi Key

RCJZXLNWNCVIMJ-XFFZJAGNSA-N

InChi Code

InChI=1S/C15H9Cl2NO/c16-12-6-5-9(8-13(12)17)7-11-10-3-1-2-4-14(10)18-15(11)19/h1-8H,(H,18,19)/b11-7-

SMILES Code

O=C1NC2=C(C=CC=C2)/C1=C/C3=CC=C(Cl)C(Cl)=C3

Appearance

Yellow solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

SU5201 is an inhibitor of interleukin-2 (IL-2) production.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	30.0	103.40
	DMF:PBS (pH 7.2) (1:2)	0.3	1.03
	DMSO	20.0	68.93

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 290.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

Oh, K. K., Adnan, M., & Cho, D. H. (2022). Network pharmacology‐based study to identify the significant pathways of Lentinula edodes against cancer. Journal of Food Biochemistry, 46(9), e14258.