Synonym
MDK71803; MDK-71803; MDK 71803; Cefiderocol-intermediate, Cefiderocol-precursor.
IUPAC/Chemical Name
4-methoxybenzyl (6R,7R)-7-((Z)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetamido)-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-oxide
SMILES Code
O=C(N[C@@H]1C(N(C(C(OCC2=CC=C(OC)C=C2)=O)=C(CCl)C3)[C@]1([H])S3=O)=O)/C(C4=CSC(NC(OC(C)(C)C)=O)=N4)=N\OC(C)(C)C(OC(C)(C)C)=O
Appearance
Yellow solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
796.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. Pharmaceutical preparation comprising cephalosporin having catechol groups with improved stability, and manufacture thereof. Kawasaki, Hidenori; Kojima, Natsuko; Fujihira, Atsushi; Takahashi, Kanako; Matsubara, Fumihiko; Matsuoka, Nao. PCT Int. Appl. (2016), WO 2016035846 A1 20160310. | Language: Japanese, Database: CAPLUS
2. Preparation of cephem compounds as antibacterial agents against β-lactamase-producing drug-resistant bacteria. Yamawaki, Kenji; Kusano, Hiroki. PCT Int. Appl. (2014), WO 2014104148 A1 20140703. | Language: Japanese, Database: CAPLUS
3. Preparation of cephem compounds having catechol group as antibacterial agents. Hisakawa, Shinya; Hasegawa, Yasushi; Aoki, Toshiaki; Kusano, Hiroki; Sano, Masayuki; Sato, Jun; Yamawaki, Kenji. PCT Int. Appl. (2011), WO 2011125967 A1 20111013. | Language: Japanese, Database: CAPLUS
4. Preparation of cephem compounds having pseudo-catechol group as antibacterial agents. Yamawaki, Kenji; Sugimoto, Hideki; Sano, Masayuki. PCT Int. Appl. (2011), WO 2011125966 A1 20111013. | Language: Japanese, Database: CAPLUS
5. Preparation of cephalosporins having catechol group as antibacterial agents
Quick View. Nishitani, Yasuhiro; Yamawaki, Kenji; Takeoka, Yusuke; Sugimoto, Hideki; Hisakawa, Shinya; Aoki, Toshiaki. PCT Int. Appl. (2010), WO 2010050468 A1 20100506. | Language: Japanese, Database: CAPLUS
6. Preparation of (piperaziniomethyl)cephalosporins. Onoue, Hiroshi; Konoike, Toshiro; Ishitobi, Hiroyuki. Eur. Pat. Appl. (1991), EP 416410 A1 19910313. | Language: English, Database: CAPLUS
