HZ-1157 | HCV inhibitor | CAS#1009734-33-1

MedKoo Cat#: 530459 | Name: HZ-1157

Description:

WARNING: This product is for research use only, not for human or veterinary use.

HZ-1157 is a hepatitis C virus (HCV) inhibitor with inhibitory activities toward HCV NS3/4A protease.

Chemical Structure

HZ-1157

CAS#1009734-33-1

Theoretical Analysis

MedKoo Cat#: 530459

Name: HZ-1157

CAS#: 1009734-33-1

Chemical Formula: C12H16N4O

Exact Mass: 232.1324

Molecular Weight: 232.29

Elemental Analysis: C, 62.05; H, 6.94; N, 24.12; O, 6.89

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
500mg	USD 2,250.00	2 Weeks
1g	USD 3,250.00	2 Weeks

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Synonym

HZ-1157; HZ 1157; HZ1157. Dengue Virus Inhibitor II.

IUPAC/Chemical Name

5-(1,1-Dimethylethoxy)- 2,4-quinazolinediamine

InChi Key

JQHKDYFLRJIBLX-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H16N4O/c1-12(2,3)17-8-6-4-5-7-9(8)10(13)16-11(14)15-7/h4-6H,1-3H3,(H4,13,14,15,16)

SMILES Code

NC1=NC(N)=C2C(OC(C)(C)C)=CC=CC2=N1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent.

In vitro activity:

Comparing the results of HZ-1157 and LZ-110618-6 in three assay systems (HCV replicon, infectious HCV and HCV NS3/4A protease), HZ-1157 showed similar IC50 values across all tests (0.73 μmol/L vs 0.82 μmol/L vs 1.0 μmol/L), indicating that HZ-1157 is a specific inhibitor of the HCV NS3/4A protease. Reference: Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. https://pubmed.ncbi.nlm.nih.gov/25066323/

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMF	5.0	0.86
	DMSO	12.5	53.81
	Ethanol	1.0	4.31

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 232.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. Yu Y, Jing JF, Tong XK, He PL, Li YC, Hu YH, Tang W, Zuo JP. Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. doi: 10.1038/aps.2014.55. Epub 2014 Jul 21. PMID: 25066323; PMCID: PMC4125721. 2. Chao B, Tong XK, Tang W, Li DW, He PL, Garcia JM, Zeng LM, Gao AH, Yang L, Li J, Nan FJ, Jacobs M, Altmeyer R, Zuo JP, Hu YH. Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. J Med Chem. 2012 Apr 12;55(7):3135-43. doi: 10.1021/jm2015952. Epub 2012 Mar 26. PMID: 22448770.

In vitro protocol:

In vivo protocol:

TBD

1: Yu Y, Jing JF, Tong XK, He PL, Li YC, Hu YH, Tang W, Zuo JP. Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A protease. Acta Pharmacol Sin. 2014 Aug;35(8):1074-81. doi: 10.1038/aps.2014.55. PubMed PMID: 25066323; PubMed Central PMCID: PMC4125721.