Tak 187 | CAS#155432-64-7 | Ergosterol Biosynthesis Inhibitor

MedKoo Cat#: 526405 | Name: Tak 187

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Tak 187 is a long-lasting ergosterol biosynthesis inhibitor.

Chemical Structure

Tak 187

CAS#155432-64-7

Theoretical Analysis

MedKoo Cat#: 526405

Name: Tak 187

CAS#: 155432-64-7

Chemical Formula: C23H20F6N6O3

Exact Mass: 542.1501

Molecular Weight: 542.44

Elemental Analysis: C, 50.93; H, 3.72; F, 21.01; N, 15.49; O, 8.85

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Tak 187, Tak187, Tak-187

IUPAC/Chemical Name

2-(2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-4-(4-(2,2,3,3-tetrafluoropropoxy)phenyl)-3(2H,4H)-1,2,4-triazolone

InChi Key

CBHTUKXHISWMTH-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H20F6N6O3/c1-14(22(37,9-33-12-30-11-31-33)18-7-2-15(24)8-19(18)25)35-21(36)34(13-32-35)16-3-5-17(6-4-16)38-10-23(28,29)20(26)27/h2-8,11-14,20,37H,9-10H2,1H3

SMILES Code

O=C1N(C(C)C(O)(C2=CC=C(F)C=C2F)CN3N=CN=C3)N=CN1C4=CC=C(OCC(F)(F)C(F)F)C=C4

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 542.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Corrales M, Cardozo R, Segura MA, Urbina JA, Basombrío MA. Comparative efficacies of TAK-187, a long-lasting ergosterol biosynthesis inhibitor, and benznidazole in preventing cardiac damage in a murine model of Chagas' disease. Antimicrob Agents Chemother. 2005 Apr;49(4):1556-60. PubMed PMID: 15793138; PubMed Central PMCID: PMC1068647. 2: Urbina JA, Payares G, Sanoja C, Molina J, Lira R, Brener Z, Romanha AJ. Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains. Int J Antimicrob Agents. 2003 Jan;21(1):39-48. PubMed PMID: 12507836. 3: Urbina JA. Specific treatment of Chagas disease: current status and new developments. Curr Opin Infect Dis. 2001 Dec;14(6):733-41. Review. PubMed PMID: 11964893. 4: Kitazaki T, Tasaka A, Hosono H, Matsushita Y, Itoh K. Optically active antifungal azoles. IX. An alternative synthetic route for 2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4- triazol-1-yl)propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]- 3(2H,4H)-1,2,4-triazolone and its analogs. Chem Pharm Bull (Tokyo). 1999 Mar;47(3):360-8. PubMed PMID: 10212386. 5: Schell WA, De Almeida GM, Dodge RK, Okonogi K, Perfect JR. In vitro and in vivo efficacy of the triazole TAK-187 against Cryptococcus neoformans. Antimicrob Agents Chemother. 1998 Oct;42(10):2630-2. PubMed PMID: 9756767; PubMed Central PMCID: PMC105909. 6: Bartroli J, Turmo E, Algueró M, Boncompte E, Vericat ML, Conte L, Ramis J, Merlos M, García-Rafanell J, Forn J. New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones. J Med Chem. 1998 May 21;41(11):1869-82. PubMed PMID: 9599237. 7: Tasaka A, Kitazaki T, Tsuchimori N, Matsushita Y, Hayashi R, Okonogi K, Itoh K. Optically active antifungal azoles. VII. Synthesis and antifungal activity of stereoisomers of 2-[(1R,2R)-2-(2, 4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl) propyl]-4-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-3(2H,4H)-1,2,4-triazo lone (TAK-187). Chem Pharm Bull (Tokyo). 1997 Feb;45(2):321-6. PubMed PMID: 9118446.