MedKoo Cat#: 530129 | Name: PNU-142731A HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

PNU-142731A HCl is mediator release inhibitor and an IL-5 production inhibitor potentially for the treatment of asthma.

Chemical Structure

PNU-142731A HCl
PNU-142731A HCl
CAS#214212-38-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 530129

Name: PNU-142731A HCl

CAS#: 214212-38-1 (HCl)

Chemical Formula: C24H31ClN6O

Exact Mass:

Molecular Weight: 455.00

Elemental Analysis: C, 63.35; H, 6.87; Cl, 7.79; N, 18.47; O, 3.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
PNU-142731A; PNU142731A; PNU 142731A
IUPAC/Chemical Name
2-(2,4-dipyrrolidin-1-ylpyrimido[4,5-b]indol-9-yl)-1-pyrrolidin-1-ylethanone;hydrochloride
InChi Key
RLFYAIUQWFELJD-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H30N6O.ClH/c31-20(27-11-3-4-12-27)17-30-19-10-2-1-9-18(19)21-22(28-13-5-6-14-28)25-24(26-23(21)30)29-15-7-8-16-29;/h1-2,9-10H,3-8,11-17H2;1H
SMILES Code
O=C(N1CCCC1)CN2C3=NC(N4CCCC4)=NC(N5CCCC5)=C3C6=C2C=CC=C6.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 214212-38-1(PNU-142731A HCl) 214212-39-2(PNU-142731A Free Base)

Preparing Stock Solutions

The following data is based on the product molecular weight 455.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Dent G. PNU-142731A Pharmacia. Curr Opin Investig Drugs. 2000 Dec;1(4):449-51. Review. PubMed PMID: 11249698. 2: Chin JE, Hatfield CA, Winterrowd GE, Krzesicki RF, Shull KL, Fidler SF, Kolbasa KP, Brashler JR, Griffin RL, Fleming WE, Justen JM, Banitt LS, Bundy GL, Richards IM. Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma. J Pharmacol Exp Ther. 1999 Jul;290(1):188-95. PubMed PMID: 10381775.