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MedKoo Cat#: 531437 | Name: ALRT 1550

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ALRT 1550 is a retinoic acid agent (RAR) agonist potentially for the treatment of cervical carcinoma.

Chemical Structure

ALRT 1550
ALRT 1550
CAS#178600-20-9

Theoretical Analysis

MedKoo Cat#: 531437

Name: ALRT 1550

CAS#: 178600-20-9

Chemical Formula: C23H32O2

Exact Mass: 340.2402

Molecular Weight: 340.51

Elemental Analysis: C, 81.13; H, 9.47; O, 9.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
LG-1550; ALRT-1550; ALRT-550; LGD-1550; LG1550; ALRT1550; ALRT550; LGD1550; LG 1550; ALRT 1550; ALRT 550; LGD 1550
IUPAC/Chemical Name
(2E,4E,6E)-7-(3,5-ditert-butylphenyl)-3-methylocta-2,4,6-trienoic acid
InChi Key
JMPZTWDLOGTBPM-OUQSKUGOSA-N
InChi Code
InChI=1S/C23H32O2/c1-16(12-21(24)25)10-9-11-17(2)18-13-19(22(3,4)5)15-20(14-18)23(6,7)8/h9-15H,1-8H3,(H,24,25)/b10-9+,16-12+,17-11+
SMILES Code
C/C(C1=CC(C(C)(C)C)=CC(C(C)(C)C)=C1)=C\C=C\C(C)=C\C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 340.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Mei JH, Wang MW. [Advances in studies on selective RXR ligands]. Yao Xue Xue Bao. 2005 Apr;40(4):294-8. Review. Chinese. PubMed PMID: 16011254. 2: Stehlin-Gaon C, Willmann D, Zeyer D, Sanglier S, Van Dorsselaer A, Renaud JP, Moras D, Schüle R. All-trans retinoic acid is a ligand for the orphan nuclear receptor ROR beta. Nat Struct Biol. 2003 Oct;10(10):820-5. PubMed PMID: 12958591. 3: Hu W, Verschraegen CF, Wu WG, Nash M, Freedman RS, Kudelka A, Kavanagh JJ. Activity of ALRT 1550, a new retinoid, with interferon-gamma on ovarian cancer cell lines. Int J Gynecol Cancer. 2002 Mar-Apr;12(2):202-7. PubMed PMID: 11975681. 4: Shalinsky DR, Bischoff ED, Lamph WW, Zhang L, Boehm MF, Davies PJ, Nadzan AM, Heyman RA. A novel retinoic acid receptor-selective retinoid, ALRT1550, has potent antitumor activity against human oral squamous carcinoma xenografts in nude mice. Cancer Res. 1997 Jan 1;57(1):162-8. PubMed PMID: 8988059. 5: Zhang L, Nadzan AM, Heyman RA, Love DL, Mais DE, Croston G, Lamph WW, Boehm MF. Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells. J Med Chem. 1996 Jul 5;39(14):2659-63. PubMed PMID: 8709094.