MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 531421 | Name: AGN 191976

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AGN 191976 is a novel thromboxane A2-mimetic.

Chemical Structure

AGN 191976
AGN 191976
CAS#159359-94-1

Theoretical Analysis

MedKoo Cat#: 531421

Name: AGN 191976

CAS#: 159359-94-1

Chemical Formula: C21H34O6

Exact Mass: 382.2355

Molecular Weight: 382.50

Elemental Analysis: Chemical Formula: C21H34O6 Exact Mass: 382.2355 Molecular Weight: 382.4970 Elemental Analysis: C, 65.94; H, 8.96; O, 25.10

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
AGN 191976
IUPAC/Chemical Name
(Z)-7-[(1R,5S,6R,7R)-7-[(3S)-3-hydroxyoctyl]-3-oxo-2,4-dioxabicyclo[3.2.1]octan-6-yl]hept-5-enoic acid
InChi Key
CVQLYMOSZQTFDP-NFUXFLSFSA-N
InChi Code
InChI=1S/C21H34O6/c1-2-3-6-9-15(22)12-13-17-16(10-7-4-5-8-11-20(23)24)18-14-19(17)27-21(25)26-18/h4,7,15-19,22H,2-3,5-6,8-14H2,1H3,(H,23,24)/b7-4-/t15-,16+,17+,18-,19+/m0/s1
SMILES Code
O=C(O)CCC/C=C\C[C@H]1[C@@]2([H])OC(O[C@@](C2)([H])[C@@H]1CC[C@@H](O)CCCCC)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 382.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Krauss AH, Woodward DF, Burk RM, Gac TS, Gibson LL, Protzman CE, Abbass F, Marshall K, Senior J. Pharmacological evidence for thromboxane receptor heterogeneity--implications for the eye. J Ocul Pharmacol Ther. 1997 Aug;13(4):303-12. PubMed PMID: 9261766. 2: Abbas F, Amin Z, Burk RM, Krauss AH, Marshall K, Senior J, Woodward DF. A comparative study of thromboxane (TP) receptor mimetics and antagonists on isolated human umbilical artery and myometrium. Adv Exp Med Biol. 1997;407:219-30. PubMed PMID: 9321956. 3: Krauss AH, Woodward DF, Gibson LL, Protzman CE, Williams LS, Burk RM, Gac TS, Roof MB, Abbas F, Marshall K, Senior J. Evidence for human thromboxane receptor heterogeneity using a novel series of 9,11-cyclic carbonate derivatives of prostaglandin F2 alpha. Br J Pharmacol. 1996 Mar;117(6):1171-80. PubMed PMID: 8882612; PubMed Central PMCID: PMC1909759. 4: Krauss AH, Woodward DF, Chen J, Gibson LL, Lai RK, Protzman CE, Shan T, Williams LS, Gac TS, Burk RM. AGN 191976: a novel thromboxane A2-mimetic with ocular hypotensive properties. J Ocul Pharmacol Ther. 1995 Fall;11(3):203-12. PubMed PMID: 8590251.