OP-2507 | CAS#101758-79-6 | prostacyclin agonist

MedKoo Cat#: 530118 | Name: OP-2507

Description:

WARNING: This product is for research use only, not for human or veterinary use.

OP-2507 is a prostacyclin agonist potentially for the treatment of hepatic insufficiency and hypertension.

Chemical Structure

OP-2507

CAS#101758-79-6

Theoretical Analysis

MedKoo Cat#: 530118

Name: OP-2507

CAS#: 101758-79-6

Chemical Formula: C25H41NO4

Exact Mass: 419.3000

Molecular Weight: 419.61

Elemental Analysis: C, 71.56; H, 9.85; N, 3.34; O, 15.25

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

OP-2507; OP2507; OP 2507

IUPAC/Chemical Name

methyl 5-[(3aR,4R,5R,6aS)-5-hydroxy-4-[(E,3S)-3-hydroxy-3-(4-propylcyclohexyl)prop-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]pyrrol-2-yl]pentanoate

InChi Key

UQEOPLABKYFAJH-FPNSLHOUSA-N

InChi Code

InChI=1S/C25H41NO4/c1-3-6-17-9-11-18(12-10-17)23(27)14-13-20-21-15-19(26-22(21)16-24(20)28)7-4-5-8-25(29)30-2/h13-14,17-18,20-24,27-28H,3-12,15-16H2,1-2H3/b14-13+/t17?,18?,20-,21-,22+,23-,24-/m1/s1

SMILES Code

O=C(OC)CCCCC1=N[C@]2([H])[C@]([C@@H](/C=C/[C@@H](O)C3CCC(CCC)CC3)[C@H](O)C2)([H])C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 419.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Usui M, Kato H, Kuriyama N, Azumi Y, Kishiwada M, Mizuno S, Sakurai H, Tabata M, Hayashi T, Suzuki K, Isaji S. Effect of a prostaglandin I(2) analog on the expression of thrombomodulin in liver and spleen endothelial cells after an extensive hepatectomy. Surg Today. 2011 Feb;41(2):230-6. doi: 10.1007/s00595-009-4263-7. PubMed PMID: 21264759. 2: Kurata M, Okajima K, Kawamoto T, Uchiba M, Ohkohchi N. Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells. World J Gastroenterol. 2006 Jan 7;12(1):60-5. PubMed PMID: 16440418; PubMed Central PMCID: PMC4077492. 3: Chen MF, Chen JC, Chiu DF, Ng CJ, Shyr MH, Chen HM. Prostacyclin analogue (OP-2507) induces delayed ex vivo neutrophil apoptosis and attenuates reperfusion-induced hepatic microcirculatory derangement in rats. Shock. 2001 Dec;16(6):473-8. PubMed PMID: 11770047. 4: Hirano T, Nakafusa Y, Kawano R, Motoyama K, Arima T, Sugitani A, Tanaka M. The combined use of prostaglandin I2 analogue (OP-2507) and thromboxane A2 synthetase inhibitor (OKY-046) strongly inhibits atherosclerosis of aortic allografts in rats. Surgery. 2001 May;129(5):595-605. PubMed PMID: 11331452. 5: Miura A, Hao Y, Koike Y, Wang LM, Honda Y, Mineshita S. The effect of the prostaglandin I2 analogue OP-2507 on adrenaline-induced pulmonary edema in rabbits and analysis of hemodynamic changes. Jpn J Pharmacol. 2000 Jun;83(2):125-34. PubMed PMID: 10928325. 6: Kuroda H, Kawarada Y, Das BC, Iwata M, Isaji S. Ultrastructural study of the remnant liver after extensive hepatectomy in dogs; especially morphological alterations of sinusoidal endothelial cells. Hepatogastroenterology. 2000 Mar-Apr;47(32):450-4. PubMed PMID: 10791211. 7: Chen HM, Chen MF, Shyr MH. Prostacyclin analogue (OP-2507) attenuates hepatic microcirculatory derangement, energy depletion, and lipid peroxidation in a rat model of reperfusion injury. J Surg Res. 1998 Dec;80(2):333-8. PubMed PMID: 9878334. 8: Iida T, Yokoi H, Kawarada Y. The effects of a thromboxane A2 synthesis inhibitor and a prostaglandin I2 analogue on experimental acute necrotizing pancreatitis in rats. Pancreas. 1998 Aug;17(2):140-7. PubMed PMID: 9700944. 9: Ochiai H, Nakamura S, Suzuki S, Baba S. Pancreatic damage resulting from temporary portal triad interruption during partial hepatectomy: protective effect of a prostaglandin I2 analogue. J Surg Res. 1997 Dec;73(2):129-36. PubMed PMID: 9441806. 10: Wang M, Sakon M, Miyoshi H, Umeshita K, Kishimoto S, Taniguchi K, Gotoh M, Imajoh-Ohmi S, Monden M. Prostacyclin analog-suppressed ischemia-reperfusion injury of the rat liver: evaluation by calpain mu activation. J Surg Res. 1997 Dec;73(2):101-6. PubMed PMID: 9441801. 11: Hirano T, Nakafusa Y, Nishinaka H, Takeda K, Kawano R, Nakano M, Arima T, Motoyama K, Nakamura K, Torada N, Ikematsu H, Kamei T, Tanaka M. Effect of prostaglandin I2 analogue and thromboxane A2 synthetase inhibitor on chronic rejection in rats. Transplant Proc. 1997 Feb-Mar;29(1-2):1520. PubMed PMID: 9123408. 12: Kim YI, Yoo YO, Park SH, Lee HI, Joo DH, Park KH, Tanamachi H. Successful transplantation of liver grafts from non-heart-beating donors by synergistic use of prostaglandins (E1 and I2 analogue) and steroids. Transplant Proc. 1997 Feb-Mar;29(1-2):1369-70. PubMed PMID: 9123343. 13: Nawata S, Sugi K, Ueda K, Nawata K, Kaneda Y, Esato K. Prostacyclin analog OP2507 prevents pulmonary arterial and airway constriction during lung preservation and reperfusion. J Heart Lung Transplant. 1996 May;15(5):470-4. PubMed PMID: 8771502. 14: Irita K, Sakai H, Yamakawa M, Nawata H, Yoshitake J, Takahashi S. Effects of OP 2507, a stable analogue of prostaglandin I2, on carbon tetrachloride-induced liver damage in starved rats. Tohoku J Exp Med. 1996 Mar;178(3):279-85. PubMed PMID: 8727710. 15: Goto S, Shimizu Y, Lord R, Vari F, Edwards-Smith C, Chiba S, Kamada N. The beneficial effect of the prostacyclin analogue (OP 2507) on rat liver transplantation subjected to an extended anhepatic phase. Transpl Int. 1996;9(6):607-10. PubMed PMID: 8914245. 16: Mashima S, Shirakami G, Mitsuyoshi A, Nakagami M, Morimoto T, Terasaki M, Nakao K, Yamabe H, Yamaoka Y, Ozawa K. Evaluation of the protective effect of a novel prostacyclin analog on mesenteric circulation following warm ischemia. Eur Surg Res. 1996;28(1):14-25. PubMed PMID: 8682140. 17: Nakano H, Monden M, Umeshita K, Murata M, Miyoshi H, Kanai T, Gotoh M, Mori T. Cytoprotective effect of prostaglandin I2 analogues on superoxide-induced hepatocyte injury. Surgery. 1994 Nov;116(5):883-9. PubMed PMID: 7940193. 18: Kim YI, Kai T, Kitano S, Ishii T, Tatsuma T, Kamada N, Sugimachi K. Hepatoprotection by a PGI2 analogue in complete warm ischemia of the pig liver. Prostanoid release from the reperfused liver. Transplantation. 1994 Oct 27;58(8):875-9. PubMed PMID: 7940729. 19: Umeki S. Prostaglandin E and analogs of prostacyclin influencing superoxide production by the human neutrophil NADPH oxidase system. Int J Biochem. 1994 Aug;26(8):1003-8. PubMed PMID: 8088410. 20: Nakano H, Monden M, Umeshita K, Murata M, Miyoshi H, Kanai T, Gotoh M, Mori T. Protective effects of prostaglandin I2 analogues on superoxide-induced hepatocyte injury. Ann N Y Acad Sci. 1994 Jun 17;723:447-50. PubMed PMID: 8030909.