ONO-1603 | CAS# 117427-00-6 | prolyl endopeptidase inhibitor

MedKoo Cat#: 530112 | Name: ONO-1603

Description:

WARNING: This product is for research use only, not for human or veterinary use.

ONO-1603 is a prolyl endopeptidase inhibitor potentially for the treatment of Alzheimer's disease.

Chemical Structure

ONO-1603

CAS#117427-00-6

Theoretical Analysis

MedKoo Cat#: 530112

Name: ONO-1603

CAS#: 117427-00-6

Chemical Formula: C16H19ClN2O3

Exact Mass: 322.1100

Molecular Weight: 322.79

Elemental Analysis: C, 59.54; H, 5.93; Cl, 10.98; N, 8.68; O, 14.87

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

ONO1603; ONO 1603; ONO-1603

IUPAC/Chemical Name

1-Pyrrolidinebutanamide,N-[(4-chlorophenyl)methyl]-2-formyl-g-oxo-, (S)

InChi Key

KGDFDVHLEYUZLN-AWEZNQCLSA-N

InChi Code

InChI=1S/C16H19ClN2O3/c17-13-5-3-12(4-6-13)10-18-15(21)7-8-16(22)19-9-1-2-14(19)11-20/h3-6,11,14H,1-2,7-10H2,(H,18,21)/t14-/m0/s1

SMILES Code

O=C(NCC1=CC=C(Cl)C=C1)CCC(N2[C@H](C=O)CCC2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 322.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Katsube N, Sunaga K, Aishita H, Chuang DM, Ishitani R. ONO-1603, a potential antidementia drug, delays age-induced apoptosis and suppresses overexpression of glyceraldehyde-3-phosphate dehydrogenase in cultured central nervous system neurons. J Pharmacol Exp Ther. 1999 Jan;288(1):6-13. PubMed PMID: 9862746. 2: Katsube N, Sunaga K, Chuang DM, Ishitani R. ONO-1603, a potential antidementia drug, shows neuroprotective effects and increases m3-muscarinic receptor mRNA levels in differentiating rat cerebellar granule neurons. Neurosci Lett. 1996 Aug 23;214(2-3):151-4. PubMed PMID: 8878106.