VU 0361737 | CAS#1161205-04-4 | mGluR-4 Modulator

MedKoo Cat#: 531331 | Name: VU 0361737

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VU0361737 is a selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu₄). It enhances mGlu₄ receptor signaling without directly activating the receptor, thereby potentiating its response to endogenous glutamate. This modulation of mGlu₄ is of interest in the treatment of neurological disorders, particularly Parkinson’s disease, due to its potential to regulate glutamatergic neurotransmission and provide neuroprotective effects.

Chemical Structure

VU 0361737

CAS#1161205-04-4

Theoretical Analysis

MedKoo Cat#: 531331

Name: VU 0361737

CAS#: 1161205-04-4

Chemical Formula: C13H11ClN2O2

Exact Mass: 262.0509

Molecular Weight: 262.69

Elemental Analysis: C, 59.44; H, 4.22; Cl, 13.49; N, 10.66; O, 12.18

Price and Availability

Size	Price	Availability
100mg	USD 450.00	2 Weeks
200mg	USD 750.00	2 Weeks
500mg	USD 1,550.00	2 Weeks

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Related CAS #

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Synonym

VU 0361737, VU-0361737, VU0361737; ML128; ML-128; ML 128;

IUPAC/Chemical Name

N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

InChi Key

ARYUXFNGXHNNDM-UHFFFAOYSA-N

InChi Code

InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)

SMILES Code

O=C(C1=NC=CC=C1)NC2=CC=C(Cl)C(OC)=C2

Appearance

White to off-white solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 262.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nguyen DV, Tran LD, Vu PNU, Meervelt LV, Nguyen MNT, Ngo AL, Duong HQ. Design, Synthesis, and Biological Evaluation of Some Novel o-aminophenol Derivatives. Curr Org Synth. 2025 Feb 7. doi: 10.2174/0115701794360303250109065121. Epub ahead of print. PMID: 39950292. 2: Timmers TG, Groen LC, Schreurs H, Bruns ER. Development and implementation of a home-based prehabilitation app for older patients undergoing elective colorectal cancer surgery. A Prospective Cohort Study. Digit Health. 2025 Feb 13;11:20552076251317760. doi: 10.1177/20552076251317760. PMID: 39949843; PMCID: PMC11822823. 3: Vu TH, An HR, Nguyen PT, Seo J, Kim CY, Park JI, Son B, Kim H, Lee HU, Kim MI. Large-sized and highly crystalline ceria nanorods with abundant Ce3+ species achieve efficient intracellular ROS scavenging. Nanoscale Horiz. 2025 Feb 14. doi: 10.1039/d4nh00639a. Epub ahead of print. PMID: 39949300. 4: Ravi NS, Mistry RD, Orsborn J, Dillon M, Tutman J, Hayes K, Wallace C, Lowe JT, Vu T. Using Point-of-Care Ultrasound to Assess Gastrostomy Balloon Placement. J Emerg Med. 2024 Oct 9:S0736-4679(24)00328-7. doi: 10.1016/j.jemermed.2024.09.017. Epub ahead of print. PMID: 39947971. 5: Thompson EW, Dong NJ, Kim JS, Bhattaru A, Vu P, Hu F, Shinohara RT, Swago S, Donnelly E, Zhang X, Loth A, Vuthuri L, Lanzilotta K, Whitehead KK, Duda J, Gee J, Almasy L, Goldmuntz E, Fogel MA, Witschey WR. Cardiovascular Magnetic Resonance Imaging Traits Associated with Adverse Right Ventricular Remodeling in Repaired Tetralogy of Fallot. J Cardiovasc Magn Reson. 2025 Feb 11:101855. doi: 10.1016/j.jocmr.2025.101855. Epub ahead of print. PMID: 39947483. 6: Tan AM, Maddison C, Ishraq F, Lim WK, Maier AB. Association of Cancer Status, Functional Outcomes, and Mortality in Australian Geriatric Rehabilitation Patients, RESORT. J Am Med Dir Assoc. 2025 Feb 10:105487. doi: 10.1016/j.jamda.2025.105487. Epub ahead of print. PMID: 39947243. 7: Puzio-Kuter AM, Xu L, McBrayer MK, Dominique R, Li HH, Fahr BJ, Brown AM, Wiebesiek AE, Russo BM, Mulligan CL, Yang H, Battaglia J, Robell KA, Thomas DH, Huang KS, Solovyov A, Greenbaum BD, Oliner JD, Davis TW, Dumble ML, Johnson ML, Xiong S, Yang P, Lozano G, Fellous MM, Vu BT, Schram AM, Levine AJ, Poyurovsky MV. Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small Molecule Reactivator. Cancer Discov. 2025 Feb 14. doi: 10.1158/2159-8290.CD-24-1421. Epub ahead of print. PMID: 39945593. 8: Lv Z, Li H, Wen C, Tian L, Chen X, Wu W, Li Z. 2D Biomimetic Membranes Constructed by Charge Assembly and Hydrogen Bonding for Precise Ion Separation. Adv Mater. 2025 Feb 13:e2419496. doi: 10.1002/adma.202419496. Epub ahead of print. PMID: 39945082. 9: Hounmanou YMG, Houefonde A; I-CRECT Consortium; Nguyen TT, Dalsgaard A. Mitigating antimicrobial resistance through effective hospital wastewater management in low- and middle-income countries. Front Public Health. 2025 Jan 29;12:1525873. doi: 10.3389/fpubh.2024.1525873. PMID: 39944563; PMCID: PMC11816359. 10: van de Wetering R, Vu LY, Kornberger LD, Luo D, Scouller B, Hong S, Paton K, Prisinzano TE, Kivell BM. Effects of Biased Analogues of the Kappa Opioid Receptor Agonist, U50,488, in Preclinical Models of Pain and Side Effects. Molecules. 2025 Jan 29;30(3):604. doi: 10.3390/molecules30030604. PMID: 39942708. 11: Montz PG, Dafni E, Neumann B, Deng D, Abdelbary MMH, Conrads G. Exploring the Genetic and Functional Diversity of Porphyromonas gingivalis Survival Factor RagAB. Int J Mol Sci. 2025 Jan 26;26(3):1073. doi: 10.3390/ijms26031073. PMID: 39940840. 12: Vu TN, Nishimura T, Osaki Y, Otani T, Yusa SI. Stability and Controlled Polymerization of Trithiocarbonate Chain Transfer Agents Under Harsh Conditions. Polymers (Basel). 2025 Jan 23;17(3):297. doi: 10.3390/polym17030297. PMID: 39940499. 13: Chen Z, Dragan M, Sun P, Haensel D, Vu R, Cui L, Zhu P, Yang N, Shi Y, Dai X. The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation. Cell Mol Immunol. 2025 Feb 13. doi: 10.1038/s41423-025-01264-z. Epub ahead of print. PMID: 39939818. 14: Elliott AM, Jana B, Vu T, Rush M, Belk A, Emmerling D, Jagannathan V, Saeugling S, Hatcher A. Building Community Resilience Through Trauma-Informed Solutions: Lessons Learned from a Social Accelerator in Rural North Carolina. Community Ment Health J. 2025 Feb 13. doi: 10.1007/s10597-024-01435-8. Epub ahead of print. PMID: 39939435. 15: Wang N, Zhang S, Langfelder P, Ramanathan L, Gao F, Plascencia M, Vaca R, Gu X, Deng L, Dionisio LE, Vu H, Maciejewski E, Ernst J, Prasad BC, Vogt TF, Horvath S, Aaronson JS, Rosinski J, Yang XW. Distinct mismatch-repair complex genes set neuronal CAG-repeat expansion rate to drive selective pathogenesis in HD mice. Cell. 2025 Feb 8:S0092-8674(25)00100-X. doi: 10.1016/j.cell.2025.01.031. Epub ahead of print. PMID: 39938516. 16: Dahl MM, Petersen PE, Christiansen DH. Genomic analysis reveals low genetic diversity and no continuous reintroduction of piscine myocarditis virus in farmed Atlantic salmon in the Faroe Islands. J Gen Virol. 2025 Feb;106(2):002068. doi: 10.1099/jgv.0.002068. PMID: 39937589; PMCID: PMC11822202. 17: Fletcher E, Sherriff A, Duijster D, de Jong-Lenters M, Ross A. Developing a Prototype Home-Based Toothbrushing Support Tool for Families in Scotland: A Mixed-Methods Study With Modified Delphi Survey and Semi-Structured Interviews. Community Dent Oral Epidemiol. 2025 Feb 12. doi: 10.1111/cdoe.13031. Epub ahead of print. PMID: 39936245. 18: Katzy RE, van Neer RHP, Ferraz MJ, Nicolai K, Passioura T, Suga H, Jongkees SAK, Artola M. Development of selective nanomolar cyclic peptide ligands as GBA1 enzyme stabilisers. RSC Chem Biol. 2025 Jan 31. doi: 10.1039/d4cb00218k. Epub ahead of print. PMID: 39936129; PMCID: PMC11808397. 19: Malik A, Brown Z, Ryder A, Balayan V, Jameson L, Vu P, Al-Jumah R, Hasoon J. Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs) for Treatment of Fibromyalgia: A Comprehensive Clinical Review. Psychopharmacol Bull. 2025 Feb 3;55(2):24-40. PMID: 39935669; PMCID: PMC11809501. 20: Overman ML, Hermans RCJ, Loukili I, Chinapaw MJM, Mehraz A, Ekkelboom L, Kremers SPJ, Renders C. A qualitative study into the perceptions and needs of fathers with a migration background on parenting regarding energy balance- related behaviors. BMC Public Health. 2025 Feb 11;25(1):565. doi: 10.1186/s12889-025-21802-8. PMID: 39934761; PMCID: PMC11818134.