MedKoo Cat#: 406965 | Name: FGFR4-IN-1
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

FGFR4-IN-1 is a potent and selective FGFR4 inhibitor. FGFR4 may be a novel therapeutic target for gastric cancer.

Chemical Structure

FGFR4-IN-1
FGFR4-IN-1
CAS#1708971-72-5

Theoretical Analysis

MedKoo Cat#: 406965

Name: FGFR4-IN-1

CAS#: 1708971-72-5

Chemical Formula: C24H27N7O5

Exact Mass: 493.2074

Molecular Weight: 493.52

Elemental Analysis: C, 58.41; H, 5.51; N, 19.87; O, 16.21

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
25mg USD 750.00 2 Weeks
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Synonym
FGFR4-IN-1; FGFR4-IN1; FGFR4-IN 1;
IUPAC/Chemical Name
N-(5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)-7-formyl-6-((3-oxomorpholino)methyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
InChi Key
ZTYSXMGILYNNJX-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H27N7O5/c1-35-7-4-26-19-10-21(27-12-18(19)11-25)29-24(34)31-5-2-3-16-9-17(20(14-32)28-23(16)31)13-30-6-8-36-15-22(30)33/h9-10,12,14H,2-8,13,15H2,1H3,(H2,26,27,29,34)
SMILES Code
O=C(N1CCCC2=CC(CN3C(COCC3)=O)=C(C=O)N=C12)NC4=NC=C(C#N)C(NCCOC)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 493.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lin H, Fu H, Sun S, Yin H, Yuan J, Liao J. Patient tissue-derived FGFR4-variant and wild-type colorectal cancer organoid development and anticancer drug sensitivity testing. Heliyon. 2024 May 14;10(10):e30985. doi: 10.1016/j.heliyon.2024.e30985. Erratum in: Heliyon. 2024 Nov 15;10(23):e39990. doi: 10.1016/j.heliyon.2024.e39990. PMID: 38826758; PMCID: PMC11141279. 2: Sun H, Song X, Li C, Li Q, Liu S, Deng N. Humanized disulfide-stabilized diabody against fibroblast growth factor-2 inhibits PD-L1 expression and epithelial-mesenchymal transition in hepatoma cells through STAT3. IUBMB Life. 2023 Nov;75(11):957-968. doi: 10.1002/iub.2766. Epub 2023 Jul 25. PMID: 37489553.