MedKoo Cat#: 530212 | Name: MK-0703

Description:

WARNING: This product is for research use only, not for human or veterinary use.

MK-0703 is a selective cyclooxygenase-2 inhibitor investigated for the treatment of acute pain and inflammation. MK-0703 at 50 and 100 mg was shown to be efficacious in the treatment of postoperative dental pain and were indistinguishable from the active comparator, ibuprofen 400 mg.

Chemical Structure

MK-0703
MK-0703
CAS#189954-93-6

Theoretical Analysis

MedKoo Cat#: 530212

Name: MK-0703

CAS#: 189954-93-6

Chemical Formula: C17H22O5S

Exact Mass: 338.1188

Molecular Weight: 338.42

Elemental Analysis: C, 60.34; H, 6.55; O, 23.64; S, 9.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
L-791515; MK-0703; L791515; MK0703; L 791515; MK 0703
IUPAC/Chemical Name
(S)-5-ethyl-3-isopropoxy-5-methyl-4-(4-(methylsulfonyl)phenyl)furan-2(5H)-one
InChi Key
FZYAFLPJDVKKQI-KRWDZBQOSA-N
InChi Code
InChI=1S/C17H22O5S/c1-6-17(4)14(15(16(18)22-17)21-11(2)3)12-7-9-13(10-8-12)23(5,19)20/h7-11H,6H2,1-5H3/t17-/m0/s1
SMILES Code
O=C1O[C@@](C)(CC)C(C2=CC=C(S(=O)(C)=O)C=C2)=C1OC(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 338.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schwartz JI, Kotey PN, Fricke JR Jr, Gottesdiener K. MK-0703 (a cyclooxygenase-2 inhibitor) in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study. Am J Ther. 2007 Jan-Feb;14(1):13-9. PubMed PMID: 17303970. 2: Single dose oral ibuprofen for acute postoperative pain in adults Christopher J Derry, Sheena Derry, R Andrew Moore, Henry J McQuay Cochrane Database Syst Rev. Author manuscript; available in PMC 2014 Sep 23.Published in final edited form as: Cochrane Database Syst Rev. 2009; (3): CD001548. Published online 2009 Jul 8. doi: 10.1002/14651858.CD001548.pub2 PMCID: PMC4171980