SSR-182289A (Free) | CAS# 363151-21-7 | thrombin inhibitor

MedKoo Cat#: 530209 | Name: SSR-182289A (Free)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SSR-182289A (Free) is a thrombin inhibitor potentially for the treatment of thrombosis. SSR-182289A had been in phase II clinical trials by Sanofi for the treatment of thrombosis. But, this research was discontinued in 2009.

Chemical Structure

SSR-182289A (Free)

CAS#363151-21-7

Theoretical Analysis

MedKoo Cat#: 530209

Name: SSR-182289A (Free)

CAS#: 363151-21-7

Chemical Formula: C30H34ClF2N5O4S

Exact Mass: 633.1988

Molecular Weight: 634.14

Elemental Analysis: C, 56.82; H, 5.40; Cl, 5.59; F, 5.99; N, 11.04; O, 10.09; S, 5.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

SSR-182289A; SSR-182289; SSR182289A; SSR182289; SSR 182289A; SSR 182289

IUPAC/Chemical Name

N-[3-[N-[4-(5-Aminopyridin-2-yl)-1(S)-[4-(difluoromethylene)piperidin-1-ylcarbonyl]butyl]sulfamoyl]biphenyl-2-yl]acetamide hydrochloride

InChi Key

JOWCHVSUAJPEIA-SNYZSRNZSA-N

InChi Code

InChI=1S/C30H33F2N5O4S.ClH/c1-20(38)35-28-25(21-7-3-2-4-8-21)10-6-12-27(28)42(40,41)36-26(11-5-9-24-14-13-23(33)19-34-24)30(39)37-17-15-22(16-18-37)29(31)32;/h2-4,6-8,10,12-14,19,26,36H,5,9,11,15-18,33H2,1H3,(H,35,38);1H/t26-;/m0./s1

SMILES Code

CC(NC1=C(S(=O)(N[C@H](C(N2CC/C(CC2)=C(F)/F)=O)CCCC3=NC=C(N)C=C3)=O)C=CC=C1C4=CC=CC=C4)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS # 362615-85-8 (HCl)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 634.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: A role for thrombin in liver fibrosis J Gillibert Duplantier, L Dubuisson, N Senant, G Freyburger, I Laurendeau, J-M Herbert, A Desmoulière, J Rosenbaum Gut. 2004 Nov; 53(11): 1682–1687. doi: 10.1136/gut.2003.032136 PMCID: PMC1774287