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MedKoo Cat#: 530205 | Name: Manifaxine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Manifaxine is a norepinephrine-dopamine reuptake inhibitor potentially for the treatment of attention deficit.

Chemical Structure

Manifaxine
Manifaxine
CAS#135306-39-7 (free base)

Theoretical Analysis

MedKoo Cat#: 530205

Name: Manifaxine

CAS#: 135306-39-7 (free base)

Chemical Formula: C12H15F2NO2

Exact Mass: 243.1071

Molecular Weight: 243.25

Elemental Analysis: C, 59.25; H, 6.22; F, 15.62; N, 5.76; O, 13.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
BW-1555U-88; GW-320659; 1555U-88; BW1555U88; GW320659; 1555U88; BW 1555U 88; GW 320659; 1555U 88
IUPAC/Chemical Name
(2S,3S,5R)-2-(3,5-Difluorophenyl)-3,5-dimethylmorpholin-2-ol
InChi Key
OZGPVYJHWWPEFT-RGNHYFCHSA-N
InChi Code
InChI=1S/C12H15F2NO2/c1-7-6-17-12(16,8(2)15-7)9-3-10(13)5-11(14)4-9/h3-5,7-8,15-16H,6H2,1-2H3/t7-,8+,12-/m1/s1
SMILES Code
O[C@]1(C2=CC(F)=CC(F)=C2)[C@H](C)N[C@H](C)CO1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS No. 135306-39-7 (Manifaxine) 135306-42-2 (Manifaxine hydrochloride)

Preparing Stock Solutions

The following data is based on the product molecular weight 243.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Spraggs CF, Pillai SG, Dow D, Douglas C, McCarthy L, Manasco PK, Stubbins M, Roses AD. Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects. Pharmacogenet Genomics. 2005 Dec;15(12):883-9. PubMed PMID: 16272960. 2: DeVeaugh-Geiss J, Conners CK, Sarkis EH, Winner PK, Ginsberg LD, Hemphill JM, Laurenza A, Barrows CE, Webster CJ, Stotka CJ, Asgharnejad M. GW320659 for the treatment of attention-deficit/hyperactivity disorder in children. J Am Acad Child Adolesc Psychiatry. 2002 Aug;41(8):914-20. PubMed PMID: 12162627.