KRP-101 | CAS# 311770-26-0 | PPARɑ agonist

MedKoo Cat#: 530204 | Name: KRP-101

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KRP-101 is a PPARɑ agonist potentially for the treatment of diabetes and hyperlipidaemia.

Chemical Structure

KRP-101

CAS#311770-26-0

Theoretical Analysis

MedKoo Cat#: 530204

Name: KRP-101

CAS#: 311770-26-0

Chemical Formula: C26H26FNO5

Exact Mass: 451.1795

Molecular Weight: 451.49

Elemental Analysis: C, 69.17; H, 5.80; F, 4.21; N, 3.10; O, 17.72

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

KRP-101; KRP 101; KRP101.

IUPAC/Chemical Name

(S)-2-(3-((4-(4-fluorophenoxy)phenyl)(methyl)carbamoyl)-4-methoxybenzyl)butanoic acid

InChi Key

GXURPXBUGUEVOP-SFHVURJKSA-N

InChi Code

InChI=1S/C26H26FNO5/c1-4-18(26(30)31)15-17-5-14-24(32-3)23(16-17)25(29)28(2)20-8-12-22(13-9-20)33-21-10-6-19(27)7-11-21/h5-14,16,18H,4,15H2,1-3H3,(H,30,31)/t18-/m0/s1

SMILES Code

CC[C@@H](CC1=CC=C(OC)C(C(N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C)=O)=C1)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 451.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Nagasawa M, Hara T, Kashino A, Akasaka Y, Ide T, Murakami K. Identification of a functional peroxisome proliferator-activated receptor (PPAR) response element (PPRE) in the human apolipoprotein A-IV gene. Biochem Pharmacol. 2009 Sep 1;78(5):523-30. doi: 10.1016/j.bcp.2009.05.007. PubMed PMID: 19433068. 2: Tsunoda M, Kobayashi N, Ide T, Utsumi M, Nagasawa M, Murakami K. A novel PPARalpha agonist ameliorates insulin resistance in dogs fed a high-fat diet. Am J Physiol Endocrinol Metab. 2008 May;294(5):E833-40. doi: 10.1152/ajpendo.00627.2007. PubMed PMID: 18212024. 3: Nagasawa M, Akasaka Y, Ide T, Hara T, Kobayashi N, Utsumi M, Murakami K. Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor alpha (PPARalpha) agonist in human hepatoma cells. Biochem Pharmacol. 2007 Dec 15;74(12):1738-46. PubMed PMID: 17904533.