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MedKoo Cat#: 530350 | Name: SF1670
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SF1670 is a specific phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor. SF1670 specifically binds to the active site of PTEN inhibiting its activity with an IC50 value of 2 μM. The innate immune responses can be enhanced and the severity of neutropenia-related infection can be alleviated by augmenting phosphatidylinositol (3,4,5)-trisphosphate in transfused neutrophils with PTEN inhibitor SF1670, providing a therapeutic strategy for improving the efficacy of granulocyte transfusion.

Chemical Structure

SF1670
CAS#345630-40-2

Theoretical Analysis

MedKoo Cat#: 530350

Name: SF1670

CAS#: 345630-40-2

Chemical Formula: C19H17NO3

Exact Mass: 307.1208

Molecular Weight: 307.35

Elemental Analysis: C, 74.25; H, 5.58; N, 4.56; O, 15.62

Price and Availability

Size Price Availability Quantity
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 2,150.00 2 Weeks
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Related CAS #
No Data
Synonym
SF1670; SF-1670; SF 1670.
IUPAC/Chemical Name
N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
InChi Key
VZQDDSYKVYARDW-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
SMILES Code
CC(C)(C)C(NC(C=C1C2=O)=CC=C1C3=C(C2=O)C=CC=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
SF 1670 is a PTPN2 and PTEN inhibitor (IC50values are 0.95 and 1.78 μM, respectively). Increases fMLP-elicited PIP3 signaling, Akt -phosphorylation and production of reactive oxygen species in neutrophils in vitro. Pretreatment of transfused neutrophils enhances chemotaxis to sites of bacterial infection and increases survival in neutropenic mice. Also inhibits CD45.
In vitro activity:
SF1670 may have potential for intervertebral disc degeneration (IVDD) treatment. SF1670 prevented nucleus pulposus (NP) degradation via suppressing apoptosis and inflammation through inhibition of PTEN and activation of Akt. SF1670 could significantly reverse the regulatory effects of IL-1β. Moreover, relative levels of IL-6, IL-8, TNF-α, and MMP3/9/13 were significantly suppressed by SF1670 stimuli compared with IL-1β group. Reference: Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):8694-8702. https://pubmed.ncbi.nlm.nih.gov/32964957/
In vivo activity:
SF1670 has potential for enhancing innate immune responses and improving the efficacy of granulocyte transfusion in neutropenia-related infections. Neutrophils treated with SF1670 had increased sensitivity to chemoattractant stimulation, enhanced functions such as phagocytosis, oxidative burst, polarization, and chemotaxis, and improved recruitment to inflamed sites. Transfusion with SF1670-treated neutrophils reduced bacterial burden in neutropenic recipient mice and alleviated severity of neutropenia-related pneumonia. Reference: Blood. 2011 Jun 16;117(24):6702-13. https://pubmed.ncbi.nlm.nih.gov/21521784/
Solvent mg/mL mM comments
Solubility
DMSO 30.7 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 307.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Tang Z, Zhao P, Zhang W, Zhang Q, Zhao M, Tan H. SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells. Aging (Albany NY). 2022 Dec 26;14(24):10081-10092. doi: 10.18632/aging.204446. Epub 2022 Dec 26. PMID: 36575044; PMCID: PMC9831741. 2. Fu HY, Shen L, Gao XS, Cui DX, Cui ZY. SF1670 inhibits apoptosis and inflammation via the PTEN/Akt pathway and thus protects intervertebral disc degeneration. Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):8694-8702. doi: 10.26355/eurrev_202009_22806. PMID: 32964957. 3. Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HR. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16;117(24):6702-13. doi: 10.1182/blood-2010-09-309864. Epub 2011 Apr 26. PMID: 21521784; PMCID: PMC3123029. 4. Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL, Cheung HH, Kung HF, Chen ZJ, Chan WY. Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. 2020 Feb 7;11(2):107. doi: 10.1038/s41419-020-2271-0. PMID: 32034125; PMCID: PMC7007436.
In vitro protocol:
1. Tang Z, Zhao P, Zhang W, Zhang Q, Zhao M, Tan H. SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells. Aging (Albany NY). 2022 Dec 26;14(24):10081-10092. doi: 10.18632/aging.204446. Epub 2022 Dec 26. PMID: 36575044; PMCID: PMC9831741. 2. Fu HY, Shen L, Gao XS, Cui DX, Cui ZY. SF1670 inhibits apoptosis and inflammation via the PTEN/Akt pathway and thus protects intervertebral disc degeneration. Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):8694-8702. doi: 10.26355/eurrev_202009_22806. PMID: 32964957.
In vivo protocol:
1. Li Y, Prasad A, Jia Y, Roy SG, Loison F, Mondal S, Kocjan P, Silberstein LE, Ding S, Luo HR. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 2011 Jun 16;117(24):6702-13. doi: 10.1182/blood-2010-09-309864. Epub 2011 Apr 26. PMID: 21521784; PMCID: PMC3123029. 2. Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL, Cheung HH, Kung HF, Chen ZJ, Chan WY. Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. 2020 Feb 7;11(2):107. doi: 10.1038/s41419-020-2271-0. PMID: 32034125; PMCID: PMC7007436.
1: Yang X, Zhou Y, Yu T, Li K, Xu S. TAN (tannic acid) inhibits BPA-induced pyroptosis of L8824 (grass carp hepatocytes) by regulating PTEN/PI3K/AKT pathway. Fish Shellfish Immunol. 2024 Mar;146:109384. doi: 10.1016/j.fsi.2024.109384. Epub 2024 Jan 20. PMID: 38246267. 2: Yang B, Wang L, Tian Z. Silencing of RhoC induces macrophage M1 polarization to inhibit migration and invasion in colon cancer via regulating the PTEN/FOXO1 pathway. Int J Exp Pathol. 2023 Feb;104(1):33-42. doi: 10.1111/iep.12460. Epub 2022 Dec 28. PMID: 36576072; PMCID: PMC9845608. 3: Tang Z, Zhao P, Zhang W, Zhang Q, Zhao M, Tan H. SALL4 activates PI3K/AKT signaling pathway through targeting PTEN, thus facilitating migration, invasion and proliferation of hepatocellular carcinoma cells. Aging (Albany NY). 2022 Dec 26;14(24):10081-10092. doi: 10.18632/aging.204446. Epub 2022 Dec 26. PMID: 36575044; PMCID: PMC9831741. 4: Fang S, Zheng L, Shen L, Su Y, Ding J, Chen W, Chen X, Chen W, Shu G, Chen M, Zhao Z, Tu J, Ji J. Inactivation of KDM5A suppresses growth and enhances chemosensitivity in liver cancer by modulating ROCK1/PTEN/AKT pathway. Eur J Pharmacol. 2023 Feb 5;940:175465. doi: 10.1016/j.ejphar.2022.175465. Epub 2022 Dec 23. PMID: 36566915. 5: Sun F, Hao W, Meng X, Xu D, Li X, Zheng K, Yu Y, Wang D, Pan W. Polyene phosphatidylcholine ameliorates synovial inflammation: involvement of PTEN elevation and glycolysis suppression. Mol Biol Rep. 2023 Jan;50(1):687-696. doi: 10.1007/s11033-022-08043-3. Epub 2022 Nov 12. PMID: 36370296. 6: Yu Z, Wu H, Wang Y. Phoenixin-14 Promotes the Recovery of Neurological Dysfunction After Spinal Cord Injury by Regulating Microglial Polarization via PTEN/Akt Signaling Pathway. Hum Exp Toxicol. 2022 Jan- Dec;41:9603271221111345. doi: 10.1177/09603271221111345. PMID: 35968813. 7: Li M, Li ZH, Song J, Li X, Zhai P, Mu X, Qiu F, Yao L. miR-205 Reverses MDR-1 Mediated Doxorubicin Resistance via PTEN in Human Liver Cancer HepG2 Cells. Cell J. 2022 Mar;24(3):112-119. doi: 10.22074/cellj.2022.7231. PMID: 35451580; PMCID: PMC9035231. 8: Zhao Y, Sun Q, Xu Z, Li M, Tian G. Effect of Ghrelin Intervention on the Ras/ERK Pathway in the Regulation of Heart Failure by PTEN. Comput Math Methods Med. 2022 Jan 17;2022:1045681. doi: 10.1155/2022/1045681. Retraction in: Comput Math Methods Med. 2023 Jul 26;2023:9761217. doi: 10.1155/2023/9761217. PMID: 35082908; PMCID: PMC8786517. 9: Sun L, Wu XX, Peng YF. [Effect of resveratrol on PTEN expression and fibrosis of renal tubular epithelial cells in a high-glucose environment]. Zhongguo Zhong Yao Za Zhi. 2021 Sep;46(18):4793-4799. Chinese. doi: 10.19540/j.cnki.cjcmm.20210520.401. PMID: 34581090. 10: Cui Z, Gao H, Yan N, Dai Y, Wang H, Wang M, Wang J, Zhang D, Sun P, Qi T, Wang Q, Kang W, Jin X. LncRNA PlncRNA-1 accelerates the progression of prostate cancer by regulating PTEN/Akt axis. Aging (Albany NY). 2021 Apr 13;13(8):12113-12128. doi: 10.18632/aging.202919. Epub 2021 Apr 13. PMID: 33848262; PMCID: PMC8109094. 11: Yue C, Bai Y, Piao Y, Liu H. DOK7 Inhibits Cell Proliferation, Migration, and Invasion of Breast Cancer via the PI3K/PTEN/AKT Pathway. J Oncol. 2021 Jan 22;2021:4035257. doi: 10.1155/2021/4035257. PMID: 33552156; PMCID: PMC7847321. 12: Niu HT, Liu Y, Wang YZ, Tian Y, Yang M, Jiang HS. Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma. Cancer Manag Res. 2021 Jan 19;13:489-497. doi: 10.2147/CMAR.S286866. Retraction in: Cancer Manag Res. 2021 Jul 19;13:5761. doi: 10.2147/CMAR.S329186. PMID: 33500662; PMCID: PMC7826076. 13: Kong J, Zhang Q, Liang X, Sun W. FOXK2 downregulation suppresses EMT in hepatocellular carcinoma. Open Med (Wars). 2020 Jul 20;15(1):702-708. doi: 10.1515/med-2020-0129. PMID: 33313412; PMCID: PMC7706124. 14: Zhang R, Zhu H, Yuan Y, Wang Y, Tian Z. SPAG6 promotes cell proliferation and inhibits apoptosis through the PTEN/PI3K/AKT pathway in Burkitt lymphoma. Oncol Rep. 2020 Nov;44(5):2021-2030. doi: 10.3892/or.2020.7776. Epub 2020 Sep 22. PMID: 33000212; PMCID: PMC7551011. 15: Fu HY, Shen L, Gao XS, Cui DX, Cui ZY. SF1670 inhibits apoptosis and inflammation via the PTEN/Akt pathway and thus protects intervertebral disc degeneration. Eur Rev Med Pharmacol Sci. 2020 Sep;24(17):8694-8702. doi: 10.26355/eurrev_202009_22806. PMID: 32964957. 16: Zhang H, Wang P, Zhang X, Zhao W, Ren H, Hu Z. SDF1/CXCR4 axis facilitates the angiogenesis via activating the PI3K/AKT pathway in degenerated discs. Mol Med Rep. 2020 Nov;22(5):4163-4172. doi: 10.3892/mmr.2020.11498. Epub 2020 Sep 9. Retraction in: Mol Med Rep. 2024 Nov;30(5):207. doi: 10.3892/mmr.2024.13331. PMID: 32901877; PMCID: PMC7533460. 17: Zhou LY, Han F, Qi SB, Ma JJ, Ma YX, Xie JL, Zhang HC, Fu XY, Chen JQ, Li B, Yang HL, Zhou F, Saijilafu. Inhibition of PTEN activity promotes IB4-positive sensory neuronal axon growth. J Cell Mol Med. 2020 Sep;24(18):11012-11017. doi: 10.1111/jcmm.15648. Epub 2020 Aug 3. PMID: 32744427; PMCID: PMC7521331. 18: Sun YY, Pan J, Wei W, Yu SS, Mao SD, Zhang N, Ai LM. Effects of miR-32 targeting PTEN on proliferation and apoptosis of myeloma cells. Eur Rev Med Pharmacol Sci. 2020 Apr;24(7):3509-3516. doi: 10.26355/eurrev_202004_20810. PMID: 32329824. 19: Fu L, Wu W, Sun X, Zhang P. Glucocorticoids Enhanced Osteoclast Autophagy Through the PI3K/Akt/mTOR Signaling Pathway. Calcif Tissue Int. 2020 Jul;107(1):60-71. doi: 10.1007/s00223-020-00687-2. Epub 2020 Apr 9. PMID: 32274533. 20: Wang W, Lu G, Su X, Tang C, Li H, Xiong Z, Leung CK, Wong MS, Liu H, Ma JL, Cheung HH, Kung HF, Chen ZJ, Chan WY. Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells. Cell Death Dis. 2020 Feb 7;11(2):107. doi: 10.1038/s41419-020-2271-0. PMID: 32034125; PMCID: PMC7007436.