Synonym
VU0652925, VU-0652925, VU 0652925, BMS-3, BMS 3, BMS3
IUPAC/Chemical Name
2-methoxy-6-(6-methoxy-4-((2-phenylthiazol-4-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole
InChi Key
RROGCGMHOWNSLD-UHFFFAOYSA-N
InChi Code
InChI=1S/C24H18N4O4S2/c1-29-16-8-19(31-12-15-13-33-22(25-15)14-6-4-3-5-7-14)17-10-21(32-20(17)9-16)18-11-28-23(26-18)34-24(27-28)30-2/h3-11,13H,12H2,1-2H3
SMILES Code
COC1=NN2C(S1)=NC(C3=CC4=C(O3)C=C(OC)C=C4OCC5=CSC(C6=CC=CC=C6)=N5)=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
490.55
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1. MOL #106666; Contributions of PAR1 and PAR4 to thrombin induced GPIIbIIIa activation in human platelets; Matthew T. Duvernay, Kayla J. Temple, Jae G. Maeng, Anna L. Blobaum, Shaun R. Stauffer, Craig W. Lindsley, Heidi E. Hamm Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232-6600, USA MTD, KJT, JGM, ALB, SRS, HEH, CWL; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA KJT, ALB, SRS, CWL; Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA SRS, CWJ Molecular Pharmacology Fast Forward. Published on October 26, 2016 as DOI: 10.1124/mol.116.106666
2. Preparation of protease activated receptor 4 (PAR4) agonist peptides and their use as PAR4 receptor activation for measuring the activity of PAR4 antagonist imidazothiadiazole and imidazopyridazine derivatives and analogs; Kornacker, Michael G.; Mapelli, Claudio; Riexinger, Douglas James
Assignee Bristol-Myers Squibb Company, USA; 2013; Patent Information; Oct 31, 2013; WO 2013163248 A1
