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MedKoo Cat#: 530333 | Name: Ro 13-3978

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RO13-3978 is a broad-spectrum antischistosomal. Ro 13-3978 showed minor in vitro activity and no damage to the tegument was found. No cytotoxicity was detected for Ro 13-3978. Ro 13-3978 was metabolically stable. Ro 13-3978 has excellent antischistosomal properties in vivo.

Chemical Structure

Ro 13-3978
Ro 13-3978
CAS# 70842-04-5

Theoretical Analysis

MedKoo Cat#: 530333

Name: Ro 13-3978

CAS#: 70842-04-5

Chemical Formula: C12H10F4N2O2

Exact Mass: 290.0678

Molecular Weight: 290.22

Elemental Analysis: C, 49.66; H, 3.47; F, 26.19; N, 9.65; O, 11.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 13-3978; Ro13-3978; Ro-13-3978; Ro 133978; Ro133978; Ro-133978.
IUPAC/Chemical Name
3-(4-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethylimidazolidine-2,4-dione
InChi Key
BTGSGTWRNQCEQY-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H10F4N2O2/c1-11(2)9(19)18(10(20)17-11)6-3-4-8(13)7(5-6)12(14,15)16/h3-5H,1-2H3,(H,17,20)
SMILES Code
FC1=C(C(F)(F)F)C=C(N2C(C(C)(C)NC2=O)=O)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 290.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Keiser J, Panic G, Vargas M, Wang C, Dong Y, Gautam N, Vennerstrom JL. Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal. J Antimicrob Chemother. 2015;70(6):1788-97. doi: 10.1093/jac/dkv016. PubMed PMID: 25691324; PubMed Central PMCID: PMC4462663. 2: Wang C, Zhao Q, Min J, Muniyan S, Vargas M, Wang X, Dong Y, Guy RK, Lin MF, Keiser J, Vennerstrom JL. Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978. Am J Trop Med Hyg. 2014 Jun;90(6):1156-8. doi: 10.4269/ajtmh.14-0029. PubMed PMID: 24686741; PubMed Central PMCID: PMC4047746. 3: Forget E, Félix H, Notteghem MJ, Léger N. [Efficacy of schistosomicide derivatives, appreciation with electronic microscopy experimental model (author's transl)]. Bull Soc Pathol Exot Filiales. 1982 Mar-Apr;75(2):192-200. French. PubMed PMID: 6809349.