MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 206761 | Name: Diethylhomospermine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Diethylhomospermine, also known as BE-4-4-4; DE-444; DEHOP; DEHSPM, is a drug potentially for the treatment of AIDS-related chronic diarrhea.Diethylhomospermine also showed promising anticancer activity.

Chemical Structure

Diethylhomospermine
CAS#119422-08-1

Theoretical Analysis

MedKoo Cat#: 206761

Name: Diethylhomospermine

CAS#: 119422-08-1

Chemical Formula: C16H38N4

Exact Mass: 286.3096

Molecular Weight: 286.51

Elemental Analysis: C, 67.08; H, 13.37; N, 19.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Diethylhomospermine; BE-4-4-4; DE-444; DEHOP; DEHSPM.
IUPAC/Chemical Name
1,14-Bis(ethylamino)-5,10-diazatetradecane
InChi Key
QXOCYGPVDXDFLC-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H38N4/c1-3-17-11-5-7-13-19-15-9-10-16-20-14-8-6-12-18-4-2/h17-20H,3-16H2,1-2H3
SMILES Code
CCNCCCCNCCCCNCCCCNCC
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 286.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Sep;26(7):587-612. Review. PubMed PMID: 15538546. 2: Wilding G, King D, Tutsch K, Pomplun M, Feierabend C, Alberti D, Arzoomanian R. Phase I trial of the polyamine analog N1,N14-diethylhomospermine (DEHSPM) in patients with advanced solid tumors. Invest New Drugs. 2004 Apr;22(2):131-8. PubMed PMID: 14739661. 3: Bergeron RJ, Wiegand J, Fannin TL. Control of irritable bowel syndrome with polyamine analogs: a structure-activity study. Dig Dis Sci. 2001 Dec;46(12):2615-23. PubMed PMID: 11768250. 4: Bergeron RJ, Weimar WR, Müller R, Zimmerman CO, McCosar BH, Yao H, Smith RE. Effect of polyamine analogues on hypusine content in JURKAT T-cells. J Med Chem. 1998 Sep 24;41(20):3901-8. PubMed PMID: 9748365. 5: Bergeron RJ, Weimar WR, Wu Q, Feng Y, McManis JS. Polyamine analogue regulation of NMDA MK-801 binding: a structure-activity study. J Med Chem. 1996 Dec 20;39(26):5257-66. PubMed PMID: 8978854. 6: Bergeron RJ, Yao GW, Yao H, Weimar WR, Sninsky CA, Raisler B, Feng Y, Wu Q, Gao F. Metabolically programmed polyamine analogue antidiarrheals. J Med Chem. 1996 Jun 21;39(13):2461-71. PubMed PMID: 8691443. 7: Bergeron RJ, Weimar WR, Luchetta G, Sninsky CA, Wiegand J. Metabolism and pharmacokinetics of N1,N14-diethylhomospermine. Drug Metab Dispos. 1996 Mar;24(3):334-43. PubMed PMID: 8820425. 8: Bergeron RJ, Wiegand J, Sninsky CA, Katovich MJ. The impact of polyamine analogues on the blood pressure of normotensive and hypertensive rats. Clin Exp Hypertens. 1995 Nov;17(8):1197-217. PubMed PMID: 8563697. 9: Chang BK, Liang Y, Miller DW, Bergeron RJ, Porter CW, Wang G. Effects of diethyl spermine analogues in human bladder cancer cell lines in culture. J Urol. 1993 Oct;150(4):1293-7. PubMed PMID: 8371417. 10: Bergeron RJ, Hawthorne TR, Vinson JR, Beck DE Jr, Ingeno MJ. Role of the methylene backbone in the antiproliferative activity of polyamine analogues on L1210 cells. Cancer Res. 1989 Jun 1;49(11):2959-64. PubMed PMID: 2720656.