MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 328097 | Name: Nerispirdine HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nerispirdine, also known as HP-184, is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibited K(v)1.1 and K(v)1.2 with IC(50) values of 3.6 and 3.7 micromol/L, respectively. Nerispirdine also inhibited voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a -70 mV holding potential.

Chemical Structure

Nerispirdine HCl
Nerispirdine HCl
CAS#119229-64-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 328097

Name: Nerispirdine HCl

CAS#: 119229-64-0 (HCl)

Chemical Formula: C17H19ClFN3

Exact Mass:

Molecular Weight: 319.81

Elemental Analysis: C, 63.85; H, 5.99; Cl, 11.08; F, 5.94; N, 13.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Nerispirdine HCl; Nerispirdine hydrochloride; HP-184; HP 184; HP184.
IUPAC/Chemical Name
N-(3-fluoropyridin-4-yl)-3-methyl-N-propyl-1H-indol-1-amine hydrochloride
InChi Key
FYIIKHJFVLTAFI-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H18FN3.ClH/c1-3-10-20(17-8-9-19-11-15(17)18)21-12-13(2)14-6-4-5-7-16(14)21;/h4-9,11-12H,3,10H2,1-2H3;1H
SMILES Code
CCCN(C1=C(F)C=NC=C1)N2C=C(C)C3=C2C=CC=C3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 119229-65-1 (Nerispirdine) 119229-64-0 (HP-184 or Nerispirdine hydrochloride)

Preparing Stock Solutions

The following data is based on the product molecular weight 319.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Schofield J, Derdau V, Atzrodt J, Zane P, Guo Z, van Horn R, Czepczor V, Stoltz A, Pardon M. Effect of deuteration on metabolism and clearance of Nerispirdine (HP184) and AVE5638. Bioorg Med Chem. 2015 Jul 1;23(13):3831-42. doi: 10.1016/j.bmc.2015.03.065. PubMed PMID: 25900628. 2: Smith C, Kongsamut S, Wang H, Ji J, Kang J, Rampe D. In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin Exp Pharmacol Physiol. 2009 Nov;36(11):1104-9. doi: 10.1111/j.1440-1681.2009.05200.x. PubMed PMID: 19413590. 3: Smith CP, Woods-Kettelberger AT, Corbett R, Chesson SM, Bores GM, Petko WW, Roehr JE, Kongsamut S. Serotonergic activity of HP 184: does spontaneous release have a role? Neurochem Res. 1996 May;21(5):575-83. PubMed PMID: 8726966. 4: Tang L, Kongsamut S. Frequency-dependent inhibition of neurotransmitter release by besipirdine and HP 184. Eur J Pharmacol. 1996 Apr 4;300(1-2):71-4. PubMed PMID: 8741167.