SUN-C5174, also known as SUNC-5174, is a 5-HT2 antagonist potentially for the treatment of arterial occlusion disease. SUN C5174 displayed the overall best profile with potent 5-HT2 receptor antagonist activity (pA2=8.98+/-0.06) and high selectivity versus other receptors. SUN C5174 showed a marked inhibitory effect on the platelet aggregation induced by serotonin in combination with collagen and adenosine diphosphate (ADP) in canine or human platelet-rich plasma (IC50=6.5 to 16 nM). Moreover, SUN-C5174 significantly inhibited the mortality rate in mouse acute pulmonary thromboembolytic death induced by collagen and serotonin at oral doses of 0.3 mg/kg or higher.
MedKoo Cat#: 530421
Name: SUN-C5174
CAS#: 191592-36-6
Chemical Formula: C22H29FN4O2
Exact Mass: 400.2275
Molecular Weight: 400.50
Elemental Analysis: C, 65.98; H, 7.30; F, 4.74; N, 13.99; O, 7.99
The following data is based on the product molecular weight 400.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
