Synonym
Sch 47896; Sch47896; Sch-47896.
IUPAC/Chemical Name
beta-Alanine, N-(N-(1-carboxy-3-(4-hydroxyphenyl)propyl)-L-phenylalanyl)-2-hydroxy-, (S-(R*,R*))-
SMILES Code
O=C(O)C[C@H](O)NC([C@H](CC1=CC=CC=C1)N[C@H](C(O)=O)CCC2=CC=C(O)C=C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
Preparing Stock Solutions
The following data is based on the
product
molecular weight
430.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Jandeleit-Dahm K, Burrell LM, Kanazawa M, Casley D, Jackson B, Johnston CI. Effects of neutral endopeptidase inhibition in the rat remnant kidney model. Kidney Blood Press Res. 1998;21(6):419-24. PubMed PMID: 9933826.
2: Yoshida K, Kanazawa M, Casley DJ, Katopothis A, Johnston CI. Inhibition of kidney neutral endopeptidase after administration of the neutral endopeptidase inhibitor candoxatril: quantitation by autoradiography. J Cardiovasc Pharmacol. 1998 Nov;32(5):702-8. PubMed PMID: 9821842.
3: Kanazawa M, Yasujima M, Kohzuki M, Abe K. [Activity and localization of neutral metalloendopeptidase (EC 3.4.24.11) (NEP), the degradative enzyme for atrial natriuretic peptide (ANP), in rat kidney]. Nihon Jinzo Gakkai Shi. 1994 Jul;36(7):791-9. Japanese. PubMed PMID: 8072216.
4: Kanazawa M, Casley DJ, Sybertz EJ, Haslanger MF, Johnston CI. Localization and characterization of neutral metalloendopeptidase (EC 3.4.24.11), the degradative enzyme for atrial natriuretic peptide, in rat kidney using a radioiodinated neutral metalloendopeptidase inhibitor. J Pharmacol Exp Ther. 1992 Jun;261(3):1231-7. PubMed PMID: 1534841.
