Sch 42495 | CAS#136511-43-8 | endopeptidase inhibitor

MedKoo Cat#: 526316 | Name: Sch 42495

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Sch 42495 is a neutral endopeptidase inhibitor.

Chemical Structure

Sch 42495

CAS#136511-43-8

Theoretical Analysis

MedKoo Cat#: 526316

Name: Sch 42495

CAS#: 136511-43-8

Chemical Formula: C20H29NO4S2

Exact Mass: 411.1538

Molecular Weight: 411.58

Elemental Analysis: C, 58.37; H, 7.10; N, 3.40; O, 15.55; S, 15.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Sch 42495; Sch-42495; Sch42495.

IUPAC/Chemical Name

N-(2(S)-(Acetylthiomethyl)-3-(2-methylphenyl)-1-oxopropyl)-L-methionine ethyl ester

InChi Key

InChi Code

SMILES Code

CSCC[C@@H](C(OCC)=O)NC([C@@H](CSC(C)=O)CC1=CC=CC=C1C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 411.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Stuhr LE. Effects of SCH 42495, a neutral endopeptidase inhibitor, on cardiac function and mass in rats after repeated hyperbaric exposures. Scand J Clin Lab Invest. 2000 Apr;60(2):141-8. PubMed PMID: 10817401. 2: SCH 42495. Drugs R D. 1999 Apr;1(4):354-6. PubMed PMID: 10566064. 3: Burrell LM, Farina N, Risvanis J, Woollard D, Casely D, Johnston CI. Inhibition of neutral endopeptidase, the degradative enzyme for natriuretic peptides, in rat kidney after oral SCH 42495. Clin Sci (Lond). 1997 Jul;93(1):43-50. PubMed PMID: 9279202. 4: Ogihara T, Rakugi H, Masuo K, Yu H, Nagano M, Mikami H. Antihypertensive effects of the neutral endopeptidase inhibitor SCH 42495 in essential hypertension. Am J Hypertens. 1994 Nov;7(11):943-7. PubMed PMID: 7848619. 5: Thompson JS, Sheedy W, Morice AH. Effects of the neutral endopeptidase inhibitor, SCH 42495, on the cardiovascular remodelling secondary to chronic hypoxia in rats. Clin Sci (Lond). 1994 Jul;87(1):109-14. PubMed PMID: 8062513. 6: Sala C, Monopoli A, Casati C, Ardeleani G, Ongini E, Zanchetti A, Morganti A. Hemodynamic and humoral effects of chronic treatment with the neutral endopeptidase inhibitor SCH 42495 in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1994 May;23(5):703-8. PubMed PMID: 7521451. 7: Richards AM, Crozier IG, Kosoglou T, Rallings M, Espiner EA, Nicholls MG, Yandle TG, Ikram H, Frampton C. Endopeptidase 24.11 inhibition by SCH 42495 in essential hypertension. Hypertension. 1993 Jul;22(1):119-26. PubMed PMID: 8391513. 8: Watkins RW, Vemulapalli S, Chiu PJ, Foster C, Smith EM, Neustadt B, Haslanger M, Sybertz EJ. Atrial natriuretic factor potentiating and hemodynamic effects of SCH 42495, a new, neutral metalloendopeptidase inhibitor. Am J Hypertens. 1993 May;6(5 Pt 1):357-68. PubMed PMID: 8512660. 9: Alton KB, Hernandez A, Alvarez N, Patrick JE. High-performance liquid chromatographic determination of N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-1-oxopropyl]-L-methionine, the active plasma metabolite of a prodrug atriopeptidase inhibitor (SCH 42495), using a thiol selective (Au/Hg) amperometric detector. J Chromatogr. 1992 Sep 2;579(2):307-17. PubMed PMID: 1429978.