SB-218795 is a potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3). SB-218795 displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. SB-218795 is active in vivo, inhibiting agonist-induced pupillary constriction.
MedKoo Cat#: 526276
Name: SB-218795
CAS#: 174635-53-1
Chemical Formula: C25H20N2O3
Exact Mass: 396.1474
Molecular Weight: 396.45
Elemental Analysis: C, 75.74; H, 5.09; N, 7.07; O, 12.11
The following data is based on the product molecular weight 396.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
