SB 210661 | CAS#162750-10-9 | 5-lipoxygenase inhibitor

MedKoo Cat#: 526262 | Name: SB 210661

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SB 210661 is a potent and selective inhibitor of 5-lipoxygenase.

Chemical Structure

SB 210661

CAS#162750-10-9

Theoretical Analysis

MedKoo Cat#: 526262

Name: SB 210661

CAS#: 162750-10-9

Chemical Formula: C16H14F2N2O4

Exact Mass: 336.0922

Molecular Weight: 336.29

Elemental Analysis: C, 57.15; H, 4.20; F, 11.30; N, 8.33; O, 19.03

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

SB 210661; SB-210661; SB210661.

IUPAC/Chemical Name

1-((3S)-6-((2,6-Difluorophenyl)methoxy)-2,3-dihydrobenzofuran-3-yl)-1-hydroxyurea

InChi Key

INZXHTIWZWAZKX-CQSZACIVSA-N

InChi Code

InChI=1S/C16H14F2N2O4/c17-12-2-1-3-13(18)11(12)7-23-9-4-5-10-14(20(22)16(19)21)8-24-15(10)6-9/h1-6,14,22H,7-8H2,(H2,19,21)/t14-/m1/s1

SMILES Code

O=C(N)N([C@@H]1COC2=CC(OCC3=C(F)C=CC=C3F)=CC=C12)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 336.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mey J, Babiuk RP, Clugston R, Zhang W, Greer JJ. Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents. Am J Pathol. 2003 Feb;162(2):673-9. PubMed PMID: 12547725; PubMed Central PMCID: PMC1851155. 2: Solomon HM, Wier PJ, Johnson CM, Posobiec LM, Rendemonti JE, Rumberger DF. Benzofuranyl ureas with potent cardiovascular teratogenicity in rats. Teratology. 2000 Mar;61(3):211-21. PubMed PMID: 10661911. 3: Salmon M, Walsh DA, Huang TJ, Barnes PJ, Leonard TB, Hay DW, Chung KF. Involvement of cysteinyl leukotrienes in airway smooth muscle cell DNA synthesis after repeated allergen exposure in sensitized Brown Norway rats. Br J Pharmacol. 1999 Jul;127(5):1151-8. PubMed PMID: 10455261; PubMed Central PMCID: PMC1566132. 4: Hisada T, Salmon M, Nasuhara Y, Chung KF. Cysteinyl-leukotrienes partly mediate eotaxin-induced bronchial hyperresponsiveness and eosinophilia in IL-5 transgenic mice. Am J Respir Crit Care Med. 1999 Aug;160(2):571-5. PubMed PMID: 10430730. 5: McLoughlin M, Kearney AS, Palepu NR. Aqueous stability of SB 210661: kinetics and primary degradation mechanisms of an N-hydroxyurea-containing 5-lipoxygenase inhibitor. J Pharm Pharmacol. 1998 Feb;50(2):127-32. PubMed PMID: 9530978.