MedKoo Cat#: 526989 | Name: KD-027

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KD-027, also known as SLx-2101, is a PDE5A inhibitor potentially for the treatment of hypertension.

Chemical Structure

KD-027
KD-027
CAS#906421-01-0

Theoretical Analysis

MedKoo Cat#: 526989

Name: KD-027

CAS#: 906421-01-0

Chemical Formula: C25H35N7O6S

Exact Mass: 561.2370

Molecular Weight: 561.66

Elemental Analysis: C, 53.46; H, 6.28; N, 17.46; O, 17.09; S, 5.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
KD-027; KD 027; KD027; SLx-2101; SLx 2101; SLx2101.
IUPAC/Chemical Name
N-(2-(dimethylamino)-2-oxoethyl)-2-(4-ethoxy-N-methyl-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)phenylsulfonamido)-N-methylacetamide
InChi Key
KMBGDFWPWSDZTL-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H35N7O6S/c1-8-10-20-26-16(3)23-25(35)27-24(28-32(20)23)18-13-17(11-12-19(18)38-9-2)39(36,37)31(7)15-22(34)30(6)14-21(33)29(4)5/h11-13H,8-10,14-15H2,1-7H3,(H,27,28,35)
SMILES Code
O=C(N(CC(N(C)C)=O)C)CN(C)S(=O)(C1=CC=C(OCC)C(C(NC2=O)=NN3C2=C(C)N=C3CCC)=C1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 561.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Paulis L, Rajkovicova R, Simko F. New developments in the pharmacological treatment of hypertension: dead-end or a glimmer at the horizon? Curr Hypertens Rep. 2015 Jun;17(6):557. doi: 10.1007/s11906-015-0557-x. Review. PubMed PMID: 25893478; PubMed Central PMCID: PMC4412646. 2: Peak TC, Yafi FA, Sangkum P, Hellstrom WJ. Emerging drugs for the treatment of erectile dysfunction. Expert Opin Emerg Drugs. 2015 Jun;20(2):263-75. doi: 10.1517/14728214.2015.1021682. Review. PubMed PMID: 25740087. 3: Kedia GT, Uckert S, Assadi-Pour F, Kuczyk MA, Albrecht K. Avanafil for the treatment of erectile dysfunction: initial data and clinical key properties. Ther Adv Urol. 2013 Feb;5(1):35-41. doi: 10.1177/1756287212466282. PubMed PMID: 23372609; PubMed Central PMCID: PMC3547533. 4: Leonardi R, Alemanni M. The management of erectile dysfunction: innovations and future perspectives. Arch Ital Urol Androl. 2011 Mar;83(1):60-2. PubMed PMID: 21585174. 5: Gur S, Sikka SC, Hellstrom WJ. Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress. Expert Opin Investig Drugs. 2008 Jun;17(6):855-64. doi: 10.1517/13543784.17.6.855 . Review. PubMed PMID: 18491987. 6: Hatzimouratidis K, Hatzichristou DG. Looking to the future for erectile dysfunction therapies. Drugs. 2008;68(2):231-50. Review. PubMed PMID: 18197727. 7: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2006 Sep;28(7):451-95. Review. PubMed PMID: 17003851.