Urolinin | Urotensin-II Receptor Agonist

MedKoo Cat#: 328067 | Name: Urolinin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Urolinin is a linear peptidic Urotensin-II Receptor Agonist. Urolinin shows low nanomolar potency as well as improved metabolic stability. Urolinin is a hexameric UIIR agonist with an EC50 of 4.75 nM and a metabolic stability of 1319 min, 6.3-fold higher than wild-type U-II. The U-II system exhibits a remarkable potential for the development of novel therapeutic strategies, especially those related to the treatment of cardiovascular diseases.

Chemical Structure

Urolinin

CAS#Unknown

Theoretical Analysis

MedKoo Cat#: 328067

Name: Urolinin

CAS#: Unknown

Chemical Formula: C45H55N11O11

Exact Mass: 925.4083

Molecular Weight: 926.00

Elemental Analysis: C, 58.37; H, 5.99; N, 16.64; O, 19.01

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Urolinin; nWWK-Tyr(3-NO2)-Abu

IUPAC/Chemical Name

(2S,5S,8S,11S,14S,17R)-11,14-bis((1H-indol-3-yl)methyl)-17,19-diamino-8-(4-aminobutyl)-2-ethyl-5-(4-hydroxy-3-nitrobenzyl)-4,7,10,13,16,19-hexaoxo-3,6,9,12,15-pentaazanonadecanoic acid

InChi Key

ZMNQEJGQZVYZOH-JYGCDXMGSA-N

InChi Code

InChI=1S/C45H55N11O11/c1-2-30(45(64)65)51-42(61)34(17-24-14-15-38(57)37(18-24)56(66)67)54-41(60)33(13-7-8-16-46)52-43(62)36(20-26-23-50-32-12-6-4-10-28(26)32)55-44(63)35(53-40(59)29(47)21-39(48)58)19-25-22-49-31-11-5-3-9-27(25)31/h3-6,9-12,14-15,18,22-23,29-30,33-36,49-50,57H,2,7-8,13,16-17,19-21,46-47H2,1H3,(H2,48,58)(H,51,61)(H,52,62)(H,53,59)(H,54,60)(H,55,63)(H,64,65)/t29-,30+,33+,34+,35+,36+/m1/s1

SMILES Code

N[C@H](CC(N)=O)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CCCCN)C(N[C@@H](CC5=CC([N+]([O-])=O)=C(O)C=C5)C(N[C@@H](CC)C(O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 926.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Urolinin: The First Linear Peptidic Urotensin-II Receptor Agonist Sebastian Bandholtz, Sarah Erdmann, Jan Lennart von Hacht, Samantha Exner, Gerd Krause, Gunnar Kleinau, and Carsten Grötzinger Publication Date (Web): October 28, 2016 (Article) DOI: 10.1021/acs.jmedchem.6b00164