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MedKoo Cat#: 526186 | Name: Ro 31-1118

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 31-1118 is a beta-adrenoceptor partial agonist.

Chemical Structure

Ro 31-1118
Ro 31-1118
CAS#86941-24-4

Theoretical Analysis

MedKoo Cat#: 526186

Name: Ro 31-1118

CAS#: 86941-24-4

Chemical Formula: C22H30FNO4

Exact Mass: 391.2159

Molecular Weight: 391.48

Elemental Analysis: C, 67.50; H, 7.72; F, 4.85; N, 3.58; O, 16.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 31-1118; Ro 311118; Ro-31-1118.
IUPAC/Chemical Name
2-Propanol, 1-(4-(2-(2-(4-fluorophenyl)ethoxy)ethoxy)phenoxy)-3-((1-methylethyl)amino)-, (+-)-
InChi Key
CYCXZGUVPDRYLG-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H30FNO4/c1-17(2)24-15-20(25)16-28-22-9-7-21(8-10-22)27-14-13-26-12-11-18-3-5-19(23)6-4-18/h3-10,17,20,24-25H,11-16H2,1-2H3
SMILES Code
OC(CNC(C)C)COC1=CC=C(OCCOCCC2=CC=C(F)C=C2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 391.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sysoliatina NA. [The effect of propranolol and flusoxolol on the lysosomal enzyme activity of the rat ventricular myocardium]. Eksp Klin Farmakol. 1992 Sep-Oct;55(5):33-6. Russian. PubMed PMID: 1363945. 2: McCaffrey PM, Riddell JG, Shanks RG. An assessment of the partial agonist activity of Ro 31-1118, flusoxolol and pindolol in man. Br J Clin Pharmacol. 1987 Nov;24(5):571-80. PubMed PMID: 2893634; PubMed Central PMCID: PMC1386328. 3: Gillies HC, Rogers HJ, Francis RJ, Galloway DB, Humphreys JE. Pharmacokinetics of single and multiple doses of flusoxolol (Ro 31-1411) in healthy subjects. Eur J Clin Pharmacol. 1986;31(1):113-5. PubMed PMID: 2877883. 4: O'Connor PC, Arnold JM, Brown AN, Francis RJ, Finch MB, Galloway DB, Harron DW, McDevitt DG, Shanks RG. Human pharmacokinetic and pharmacodynamic studies on Ro31-1118, a new beta-adrenoceptor antagonist. Br J Clin Pharmacol. 1985 Mar;19(3):319-27. PubMed PMID: 2859047; PubMed Central PMCID: PMC1463730. 5: Jamieson M, Petrie JC, Webster J, Miller A, Harris RI, Francis RJ. Ro 31-1118, a new cardioselective beta-adrenoceptor antagonist. Pharmacokinetics and effects on heart rate and blood pressure in mild hypertensives. Eur J Clin Pharmacol. 1985;29(4):395-9. PubMed PMID: 2868899.