Ro 48-6791 | CAS#172407-17-9 | GABA receptor agonist

MedKoo Cat#: 526949 | Name: Ro 48-6791

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 48-6791 is a GABA receptor agonist potentially for the use of anesthesia.

Chemical Structure

Ro 48-6791

CAS#172407-17-9

Theoretical Analysis

MedKoo Cat#: 526949

Name: Ro 48-6791

CAS#: 172407-17-9

Chemical Formula: C21H25FN6O2

Exact Mass: 412.2023

Molecular Weight: 412.47

Elemental Analysis: C, 61.15; H, 6.11; F, 4.61; N, 20.38; O, 7.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Ro 48-6791; Ro48-6791; Ro-48-6791; Ro 486791; Ro486791; Ro-486791.

IUPAC/Chemical Name

3-[5-[(dipropylamino)methyl]-1,2,4-oxadiazol-3-yl]-8-fluoro-5-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-6-one

InChi Key

NOQIYRGMEFBZTI-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H25FN6O2/c1-4-8-27(9-5-2)12-18-24-20(25-30-18)19-17-11-26(3)21(29)15-10-14(22)6-7-16(15)28(17)13-23-19/h6-7,10,13H,4-5,8-9,11-12H2,1-3H3

SMILES Code

O=C1N(C)CC2=C(C3=NOC(CN(CCC)CCC)=N3)N=CN2C4=CC=C(F)C=C14

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 412.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Olkkola KT, Ahonen J. Midazolam and other benzodiazepines. Handb Exp Pharmacol. 2008;(182):335-60. doi: 10.1007/978-3-540-74806-9_16. Review. PubMed PMID: 18175099. 2: Ihmsen H, Albrecht S, Hering W, Schüttler J, Schwilden H. Modelling acute tolerance to the EEG effect of two benzodiazepines. Br J Clin Pharmacol. 2004 Feb;57(2):153-61. PubMed PMID: 14748814; PubMed Central PMCID: PMC1884442. 3: Gold ME, Todd SA, Spiegler C, Gold JA. When the drug trial fails: an approach to clinical drug studies. AANA J. 1999 Dec;67(6):505-12. PubMed PMID: 10876442. 4: Tang J, Wang B, White PF, Gold M, Gold J. Comparison of the sedation and recovery profiles of Ro 48-6791, a new benzodiazepine, and midazolam in combination with meperidine for outpatient endoscopic procedures. Anesth Analg. 1999 Oct;89(4):893-8. PubMed PMID: 10512261. 5: Schoemaker RC, van Gerven JM, Cohen AF. Estimating potency for the Emax-model without attaining maximal effects. J Pharmacokinet Biopharm. 1998 Oct;26(5):581-93. PubMed PMID: 10205772. 6: Wrigley PJ, Elliott DW, Blake D. A phase 2 clinical trial comparing Ro 48-6791, a new short-acting benzodiazepine, with propofol for induction of anaesthesia. Anaesth Intensive Care. 1998 Oct;26(5):509-14. PubMed PMID: 9807605. 7: Dingemanse J, van Gerven JM, Schoemaker RC, Roncari G, Oberyé JJ, van Oostenbruggen MF, Massarella J, Segala P, Zell M, Cohen AF. Integrated pharmacokinetics and pharmacodynamics of Ro 48-6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects. Br J Clin Pharmacol. 1997 Nov;44(5):477-86. PubMed PMID: 9384465; PubMed Central PMCID: PMC2042878. 8: Dingemanse J, Häussler J, Hering W, Ihmsen H, Albrecht S, Zell M, Schwilden H, Schüttler J. Pharmacokinetic-pharmacodynamic modelling of the EEG effects of Ro 48-6791, a new short-acting benzodiazepine, in young and elderly subjects. Br J Anaesth. 1997 Nov;79(5):567-74. PubMed PMID: 9422892. 9: Zell M, Husser C, Hopfgartner G. Low picogram determination of Ro 48-6791 and its major metabolite, Ro 48-6792, in plasma with column-switching microbore high-performance liquid chromatography coupled to ion spray tandem mass spectrometry. Rapid Commun Mass Spectrom. 1997;11(10):1107-14. PubMed PMID: 9218357. 10: Hering W, Ihmsen H, Albrecht S, Schwilden H, Schüttler J. [RO 48-6791--a short acting benzodiazepine. Pharmacokinetics and pharmacodynamics in young and old subjects in comparison to midazolam]. Anaesthesist. 1996 Dec;45(12):1211-4. German. PubMed PMID: 9065257.