MedKoo Cat#: 329309 | Name: Bencyclane Fumarate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bencyclane Fumarate, also known as Halidor, is a vasodilator agent found to be effective in a variety of peripheral circulation disorders. Bencyclane Fumarate's mechanism may involve blocking of calcium channels.

Chemical Structure

Bencyclane Fumarate
Bencyclane Fumarate
CAS#14286-84-1(fumarate)

Theoretical Analysis

MedKoo Cat#: 329309

Name: Bencyclane Fumarate

CAS#: 14286-84-1(fumarate)

Chemical Formula: C23H35NO5

Exact Mass: 405.2515

Molecular Weight: 405.54

Elemental Analysis: C, 68.12; H, 8.70; N, 3.45; O, 19.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Bencyclane Fumarate; Halidor; Angiociclan; Angiodel; Diacyclan; Hemoflux;
IUPAC/Chemical Name
3-((1-benzylcycloheptyl)oxy)-N,N-dimethylpropan-1-amine fumarate
InChi Key
LSTKNZAMFRGXCG-WLHGVMLRSA-N
InChi Code
InChI=1S/C19H31NO.C4H4O4/c1-20(2)15-10-16-21-19(13-8-3-4-9-14-19)17-18-11-6-5-7-12-18;5-3(6)1-2-4(7)8/h5-7,11-12H,3-4,8-10,13-17H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES Code
CN(CCCOC1(CC2=CC=CC=C2)CCCCCC1)C.O=C(O)/C=C/C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# 2179-37-5 (Bencyclane) 14286-84-1 (Bencyclane Fumarate)

Preparing Stock Solutions

The following data is based on the product molecular weight 405.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Barut I, Tarhan OR, Kapucuoglu N, Sutcu R, Akdeniz Y. Effect of bencyclane fumarate on intestinal ischaemia reperfusion injury. ANZ J Surg. 2008 Jun;78(6):476-81. doi: 10.1111/j.1445-2197.2008.04358.x. PubMed PMID: 18522569. 2: Fujioka K, Kurosaki Y, Sato S, Noguchi T, Noguchi T, Yamahira Y. Biopharmaceutical study of inclusion complexes. I. Pharmaceutical advantages of cyclodextrin complexes of bencyclane fumarate. Chem Pharm Bull (Tokyo). 1983 Jul;31(7):2416-23. PubMed PMID: 6640805. 3: Cavallini L, Lucchetti G. [Effect of bencyclane fumarate on brain metabolism in the rat--in vitro study]. Boll Chim Farm. 1977 Aug;116(8):473-83. French. PubMed PMID: 921852. 4: Hockwin O, Korte I, Breuer R, Schmidt G, Rast-Czyborra F. [In vitro incubation of lenses. Model for testing substrate utilization of substances of the energy metabolism, demonstrated with bencyclane-hydrogen-fumarate (author's transl)]. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1978 Aug 16;207(3):169-80. German. PubMed PMID: 309736. 5: Hockwin O, Korte I, Loth C, Ohrloff C, Fuss R, Schmidt G. Action of bencyclane-hydrogen-fumarate on the carbohydrate metabolism of bovine lens homogenates. Arzneimittelforschung. 1977 Jul;27(7):1417-20. PubMed PMID: 578465. 6: Schumann J. [The effect of bencyclane hydrogen fumarate (Fludilate) on the adhesion of tumor cells in vivo and in vitro]. Fortschr Med. 1976 Sep 16;94(26):1429-32. German. PubMed PMID: 61934. 7: Mohri Z, Yasuda T, Kawahara K, Shono F, Yoshitake A. Radioimmunoassay of bencyclane in human serum. J Pharmacobiodyn. 1985 Mar;8(3):227-33. PubMed PMID: 4009414. 8: Bock PR. A contribution to the pharmacokinetics of bencyclane (Fludilat) in man. Int J Clin Pharmacol Biopharm. 1976 Jun;13(4):246-52. PubMed PMID: 965131. 9: Gawrych Z, Szyszko E. [Coulometric determination of bencyclane hydrogen fumarate in substance and tablets]. Acta Pol Pharm. 1978;35(6):695-6. Polish. PubMed PMID: 742400. 10: Gielsdorf W, Settlage JA, Jaeger H. Quantitative determination of bencyclane in human plasma by capillary gas chromatography/chemical ionization mass spectrometry. Arzneimittelforschung. 1984;34(3):290-2. PubMed PMID: 6539608. 11: Magdalan J, Antończyk A, Kochman K, Porebska B. [Severe bencyctane intoxication--a case report]. Przegl Lek. 2007;64(4-5):301-3. Polish. PubMed PMID: 17724891. 12: Berezhnaya SV, Yakupov EZ. [The neuroprotective therapy of outpatient treatment of chronic cerebral ischemia]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(6):48-52. Russian. PubMed PMID: 26356397. 13: Kimura K, Nagata A, Miyawaki H. The metabolism of benzyclane [1-benzyl-1-(3-N,N-dimethylaminopropoxy)cycloheptane] in rat and man. Xenobiotica. 1979 Feb;9(2):119-27. PubMed PMID: 433310. 14: Koçak R, Başlamişli F, Güvenç B, Tamer L, Aikimbaev KS, Isbir T. Bencyclane as an anti-sickling agent. Br J Haematol. 1996 Feb;92(2):329-31. PubMed PMID: 8602994. 15: Yang S, Wang X, Guo H, Dong G, Peng B, Qiu J, Zhang R, Shi Y. Broadband near-infrared emission in Tm3+-Dy3+ codoped amorphous chalcohalide films fabricated by pulsed laser deposition. Opt Express. 2011 Dec 19;19(27):26529-35. doi: 10.1364/OE.19.026529. PubMed PMID: 22274237.