RO 23-6152 | CAS#108383-96-6 | calcium antagonist

MedKoo Cat#: 526172 | Name: RO 23-6152

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RO 23-6152 is a new calcium antagonist that can inhibit platelet aggregation in vitro associated with occlusive coronary thrombus formation.

Chemical Structure

RO 23-6152

CAS#108383-96-6

Theoretical Analysis

MedKoo Cat#: 526172

Name: RO 23-6152

CAS#: 108383-96-6

Chemical Formula: C26H29ClN2O4S

Exact Mass:

Molecular Weight: 501.04

Elemental Analysis: C, 62.33; H, 5.83; Cl, 7.08; N, 5.59; O, 12.77; S, 6.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

RO 23-6152; RO 236152; RO-23-6152.

IUPAC/Chemical Name

(+)-cis-3-(Acetyloxy)-2,3-dihydro-2-(4-methoxyphenyl)-5-(2-(dimethylamino)ethyl)naptho-(1,2-b)-1,4-thiazepin-4(5H)one HCl

InChi Key

SFTBZKFGODNAKF-ITNPDYSASA-N

InChi Code

InChI=1S/C26H28N2O4S.ClH/c1-17(29)32-23-24(19-9-12-20(31-4)13-10-19)33-25-21-8-6-5-7-18(21)11-14-22(25)28(26(23)30)16-15-27(2)3;/h5-14,23-24H,15-16H2,1-4H3;1H/t23-,24+;/m1./s1

SMILES Code

O=C1N(CCN(C)C)C2=CC=C3C=CC=CC3=C2S[C@@H](C4=CC=C(OC)C=C4)[C@H]1OC(C)=O.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 501.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sordahl LA, Rex KA, Benedict CR. In vivo inhibition of platelet aggregation and occlusive coronary thrombus formation by a new calcium antagonist (R023-6152). J Cardiovasc Pharmacol. 1991 Oct;18(4):504-10. PubMed PMID: 1724526. 2: Medh JD, Rex KA, Benedict CR, Sordahl LA. In vitro and in vivo effects of R023-6152 on heart mitochondrial calcium and energy metabolism. J Cardiovasc Pharmacol. 1991 Oct;18(4):473-7. PubMed PMID: 1724522. 3: Folkers HB, van Zwienen JC, Boer P, Kleinbloesem CH, Geyskes GG. Hemodynamic effects of Ro 23-6152 in patients with essential hypertension. Eur J Clin Pharmacol. 1991;41(4):307-11. PubMed PMID: 1804644.