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MedKoo Cat#: 526168 | Name: Ro 22-9194

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 22-9194 is a new class I antiarrhythmic agent. Ro 22-9194 (⩾10 μM) caused a concentration-dependent decrease in the maximum upstroke velocity (V̇max) and shortening of action potential duration in guinea-pig ventricular cells.

Chemical Structure

Ro 22-9194
Ro 22-9194
CAS#106134-33-2

Theoretical Analysis

MedKoo Cat#: 526168

Name: Ro 22-9194

CAS#: 106134-33-2

Chemical Formula: C19H25N3O

Exact Mass: 311.1998

Molecular Weight: 311.43

Elemental Analysis: C, 73.28; H, 8.09; N, 13.49; O, 5.14

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ro 22-9194; Ro 229194; Ro-22-9194.
IUPAC/Chemical Name
2-Amino-N-(2,6-dimethylphenyl)-N-(3-(3-pyridyl)propyl)propionamide
InChi Key
YYGZCHLVUTUNGZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H25N3O/c1-14-7-4-8-15(2)18(14)22(19(23)16(3)20)12-6-10-17-9-5-11-21-13-17/h4-5,7-9,11,13,16H,6,10,12,20H2,1-3H3
SMILES Code
CC(N)C(N(C1=C(C)C=CC=C1C)CCCC2=CC=CN=C2)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 311.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hisatome I, Tanaka Y, Sasaki N, Hiroe K, Ahmmed GU, Tsuboi M, Manabe I, Suga T, Yamamoto Y, Ohtahara A, Kinugawa T, Ogino K, Igawa O, Yoshida A, Saito M, Sato R, Shigemasa C. Influence of extracellular H+ and Ca2+ on Ro 22-9194-induced block of sodium current in cardiac myocytes. Gen Pharmacol. 1997 Oct;29(4):557-60. PubMed PMID: 9352302. 2: Karasaki S, Sato R, Katori R. The blocking mechanism of sodium currents by a new class I antiarrhythmic drug, Ro 22-9194, in isolated guinea-pig ventricular myocytes. Gen Pharmacol. 1997 Sep;29(3):379-86. PubMed PMID: 9378244. 3: Hiroe K, Hisatome I, Tanaka Y, Ahmmed GU, Sasaki N, Shimoyama M, Tsuboi M, Inoue Y, Manabe I, Yamamoto Y, Ohtahata A, Kinugawa T, Ogino K, Igawa O, Yoshida A, Shigemasa C, Sato R. Tonic block of the Na+ current in single atrial and ventricular guinea-pig myocytes, by a new antiarrhythmic drug, Ro 22-9194. Fundam Clin Pharmacol. 1997;11(5):402-7. PubMed PMID: 9342593. 4: Murakami M, Kinukawa M, Kanazawa T, Maruyama K, Miyagi M, Miyata H, Ujiie A. Effects of the new class I antiarrhythmic agent Ro 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate, on ischemia- and reperfusion-induced arrhythmias in dogs: involvement of thromboxane A2 synthase inhibitory activity. J Pharmacol Exp Ther. 1996 Nov;279(2):877-83. PubMed PMID: 8930195. 5: Kodama I, Maruyama K, Suzuki R, Honjo H, Toyama J. Electropharmacology of Ro 22-9194, a new antiarrhythmic agent. Gen Pharmacol. 1996 Jul;27(5):755-60. Review. PubMed PMID: 8842676. 6: Maruyama K, Kodama I, Anno T, Suzuki R, Toyama J. Electrophysiological effects of Ro 22-9194, a new antiarrhythmic agent, on guinea-pig ventricular cells. Br J Pharmacol. 1995 Jan;114(1):19-26. PubMed PMID: 7712017; PubMed Central PMCID: PMC1510164. 7: Murakami M, Furukawa Y, Karasawa Y, Ren LM, Takei M, Narita M, Chiba S. Cardiovascular effects of R- and S-enantiomers of Ro 22-9194, (2R)-2-amino-N- (2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide D-tartrate and (2S)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide L-tartrate, in dog heart preparations. J Cardiovasc Pharmacol. 1992 Jul;20(1):165-71. PubMed PMID: 1383626. 8: Murakami M, Furukawa Y, Karasawa Y, Ren LM, Chiba S. Cardiovascular effects of 2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyl]propionamide dihydrochloride (Ro 22-9194) in the isolated, cross-perfused atrium of the dog. Jpn Heart J. 1990 Sep;31(5):731-9. PubMed PMID: 2273560.

View History

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