Synonym
Ro 18-5364; Ro 185364; Ro-18-5364.
IUPAC/Chemical Name
5,7-Dihydro-2-(((4-methoxy-3-methyl-2-pyridyl)methyl)sulfinyl)-5,5,7,7-tetramethylindeno(5,6-d)imidazol-6(1H)-one
InChi Key
YBCJDBBYBFMVEG-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H25N3O3S/c1-12-17(23-8-7-18(12)28-6)11-29(27)20-24-15-9-13-14(10-16(15)25-20)22(4,5)19(26)21(13,2)3/h7-10H,11H2,1-6H3,(H,24,25)
SMILES Code
O=C1C(C)(C)C2=C(C=C3NC(S(CC4=NC=CC(OC)=C4C)=O)=NC3=C2)C1(C)C
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
411.52
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Belaz KR, Coimbra M, Barreiro JC, Montanari CA, Cass QB. Multimilligram enantioresolution of sulfoxide proton pump inhibitors by liquid chromatography on polysaccharide-based chiral stationary phase. J Pharm Biomed Anal. 2008 May 12;47(1):81-7. doi: 10.1016/j.jpba.2007.12.018. PubMed PMID: 18242919.
2: Bastaki SM, Chandranath I, Garner A. Comparison of five antisecretory agents acting via gastric H+/K+-ATPase. J Physiol Paris. 2000 Jan-Feb;94(1):19-23. PubMed PMID: 10761684.
3: Guinotte F, Gautron J, Soumarmon A, Robert JC, Peranzi G, Nys Y. Gastric acid secretion in the chicken: effect of histamine H2 antagonists and H+/K(+)-ATPase inhibitors on gastro-intestinal pH and of sexual maturity calcium carbonate level and particle size on proventricular H+/K+ ATPase activity. Comp Biochem Physiol Comp Physiol. 1993 Oct;106(2):319-27. PubMed PMID: 7902802.
4: Morii M, Takata H, Fujisaki H, Takeguchi N. The potency of substituted benzimidazoles such as E3810, omeprazole, Ro 18-5364 to inhibit gastric H+, K(+)-ATPase is correlatedwith the rate of acid-activation of the inhibitor. Biochem Pharmacol. 1990 Feb 15;39(4):661-7. PubMed PMID: 2154989.
5: Sigrist-Nelson K, Krasso A, Müller RK, Fischli AE. Ro 18-5364, a potent new inhibitor of the gastric (H+ + K+)-ATPase. Eur J Biochem. 1987 Jul 15;166(2):453-9. PubMed PMID: 3038541.
6: Sigrist-Nelson K, Müller RK, Fischli AE. Gastric (H+ + K+)-ATPase: modulation of the inhibitory properties of the novel potent antisecretagogue Ro 18-5364 by sulfhydryl reagents and nucleotides. FEBS Lett. 1986 Mar 3;197(1-2):187-91. PubMed PMID: 3005040.
