Ro 18-3981 inhibits myocardial Ca2+ channels. The KD value of Ro 18-3981 (1.0 nM) was similar to the IC50 value for blockade of ICa at a Vh of -20 mV (2.3 nM), i.e. at a level of near-maximal depolarization.
MedKoo Cat#: 526160
Name: Ro 18-3981
CAS#: 103295-92-7
Chemical Formula: C24H33N3O8S-
Exact Mass: 523.1994
Molecular Weight: 523.60
Elemental Analysis: C, 55.05; H, 6.35; N, 8.03; O, 24.44; S, 6.12
The following data is based on the product molecular weight 523.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
