MedKoo Cat#: 526159 | Name: Ro 17-1812

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ro 17-1812 is a benzodiazepine receptor partial agonist.

Chemical Structure

Ro 17-1812
Ro 17-1812
CAS#90450-01-4

Theoretical Analysis

MedKoo Cat#: 526159

Name: Ro 17-1812

CAS#: 90450-01-4

Chemical Formula: C18H16ClN3O3

Exact Mass: 357.0880

Molecular Weight: 357.79

Elemental Analysis: C, 60.43; H, 4.51; Cl, 9.91; N, 11.74; O, 13.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Ro 17-1812; Ro 171812; Ro-17-1812.
IUPAC/Chemical Name
9H,11H-Azeto(2,1-c)imidazo(1,5-a)(1,4)benzodiazepine-1-carboxylic acid, 8-chloro-12,12a-dihydro-9-oxo-, cyclopropylmethyl ester, (S)-
InChi Key
HFTSPQUXYIMHAN-ZDUSSCGKSA-N
InChi Code
InChI=1S/C18H16ClN3O3/c19-11-2-1-3-12-14(11)17(23)21-7-6-13(21)16-15(20-9-22(12)16)18(24)25-8-10-4-5-10/h1-3,9-10,13H,4-8H2/t13-/m0/s1
SMILES Code
O=C(C1=C([C@@]2([H])N3CC2)N(C=N1)C4=CC=CC(Cl)=C4C3=O)OCC5CC5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 357.79 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cooper SJ, Green AE. The benzodiazepine receptor partial agonists, bretazenil (Ro 16-6028) and Ro 17-1812, affect saccharin preference and quinine aversion in the rat. Behav Pharmacol. 1993 Feb;4(1):81-85. PubMed PMID: 11224174. 2: Feely M, Boyland P, Picardo A, Cox A, Gent JP. Lack of anticonvulsant tolerance with RU 32698 and Ro 17-1812. Eur J Pharmacol. 1989 May 19;164(2):377-80. PubMed PMID: 2759183. 3: Potier MC, Prado de Carvalho L, Venault P, Chapouthier G, Rossier J. Demonstration of the partial agonist profiles of Ro 16-6028 and Ro 17-1812 in mice in vivo. Eur J Pharmacol. 1988 Oct 26;156(1):169-72. PubMed PMID: 2850207. 4: Saletu B, Grünberger J, Linzmayer L. Early clinical pharmacological trials with a novel partial benzodiazepine agonist/antagonist Ro 17-1812 using pharmaco-EEG and psychometry. Methods Find Exp Clin Pharmacol. 1986 Jun;8(6):373-89. PubMed PMID: 3736281.